Zhang Gui-Feng, Huang Yong, Tang Chun-Zhi, Wang Shu-Xia, Yang Jun-Jun, Shan Bao-Ci
School of Chinese Medicine, Southern Medical University, Guangzhou 510515, China.
Zhen Ci Yan Jiu. 2011 Feb;36(1):46-51.
To observe the characteristics of needling sensation of "Deqi" (feelings of soreness, numbness, distending and heaviness, SNDH) by using positron emission tomography (PET) based on changes of glucose metabolism in different functional brain areas.
Eighteen normal volunteers [9 men and 9 women, mean age (23.23-1- 3. 32) years] were randomly divided into control, Waiguan (SJ 5) and non-acupoint groups (n=6 in each group). SJ 5 and non-acupoint (the midpoint between SJ 5 and the running course of the Small Intestine Meridian on the right forearm) were punctured by using a sterilized filiform needle. PET scan of the brain began 40 min after intravenous 18 F-fluorodeoxyglucose (FDG) injection (0. 11 mCi/kg body weight, left opisthenar vein). Needling sensations including "Deqi"(n= 5), tingling (n 5) and no-apparently-specific-feeling (NASF) were acquired by acupuncture stimulation and grouped. The needling sensations were evaluated by using Visual Analog Scale(VAS). The acquired image data of different needling-sensation groups were analyzed using SPM 2. 0 software in the Matlab Platform.
After receiving acupuncture stimulation of SJ 5, 5 volunteers in the Waiguan (SJ 5) group experienced fee- lings of SNDH, with the mean VAS score being 4.23 +/- 1. 50, and 5 volunteers of the non-acupoint group had a tingling feeling, with the mean VAS score being 5.73 2.40. The VAS score of the tingling group was significantly higher than that of SNDH group (P<0. 05). Compared with the NASF control group, the activated cerebral areas were Brodmann area (BA) 7, 13, 20, 22, 39, 42 and BA 45 in the SNDH group, mainly involving the left temporal lobe, superior temporal gyrus, etc. and being obviously different to those of the control group (P<0. 001,k>10 voxels). The activated cerebral areas in the tingling group were BA 18, 19, 22, 24, 25, 32, 36, 40 and BA 45, predominantly involving the left limbic lobe, hippocampal gyrus, etc. and being apparently different to those of the control group (P<0. 001,k> 10 voxels).
Acupuncture of Waiguan (SJ 5) mainly produces feelings of soreness, numbness, distending and heaviness, and the activated cerebral areas mainly involve the left temporal lobe, superior temporal gyrus, etc. ; while acupuncture of its neighboring non-acupoint chiefly induces a feeling of tingling in the healthy subjects, and the activated regions predominately involve the left limbic lobe, hippocampal gyrus, etc.
基于不同功能脑区葡萄糖代谢变化，采用正电子发射断层扫描（PET）观察“得气”（酸、麻、胀、重感，SNDH）的针感特征。
18名正常志愿者[9名男性和9名女性，平均年龄（23.23±3.32）岁]被随机分为对照组、外关（SJ 5）组和非穴位组（每组n = 6）。使用消毒毫针针刺SJ 5和非穴位（SJ 5与右侧前臂小肠经走行中点）。静脉注射18F - 氟脱氧葡萄糖（FDG）（0.11 mCi/kg体重，左后手背静脉）40分钟后开始脑部PET扫描。通过针刺刺激获得包括“得气”（n = 5）、刺痛（n = 5）和无明显特异性感觉（NASF）的针感并分组。使用视觉模拟评分法（VAS）评估针感。在Matlab平台上使用SPM 2.0软件分析不同针感组获得的图像数据。
外关（SJ 5）组5名志愿者在针刺SJ 5后出现酸、麻、胀、重感，平均VAS评分为4.23±1.50，非穴位组5名志愿者有刺痛感，平均VAS评分为5.73±2.40。刺痛组的VAS评分显著高于得气组（P < 0.05）。与NASF对照组相比，得气组激活的脑区为Brodmann区（BA）7、13、20、22、39、42和BA 45，主要涉及左侧颞叶、颞上回等，与对照组明显不同（P < 0.001，k > 10体素）。刺痛组激活的脑区为BA 18、19、22、24、25、32、36、40和BA 45，主要涉及左侧边缘叶、海马回等，与对照组明显不同（P < 0.001，k > 10体素）。
针刺外关（SJ 5）主要产生酸、麻、胀、重感，激活的脑区主要涉及左侧颞叶、颞上回等；而针刺其邻近非穴位在健康受试者中主要诱发刺痛感，激活区域主要涉及左侧边缘叶、海马回等。
