Scientific Center of Clinical and Experimental Medicine, Siberian Branch of the Russian Academy of Medical Sciences, Novosibirsk, Russia.
Biochemistry (Mosc). 2011 Apr;76(4):407-22. doi: 10.1134/s0006297911040031.
Nrf2 regulates expression of genes containing antioxidant-respons(iv)e element (ARE) in their promoters and plays a pivotal role among all redox-sensitive transcription factors. Nrf2 is constitutively controlled by repressor protein Keap1, which acts as a molecular sensor of disturbances in cellular homeostasis. These molecular patterns are in close interconnection and function as parts of the integrated redox-sensitive signaling system Nrf2/Keap1/ARE. Depending on cellular redox balance, activity of this signaling system changes at the levels of transcription, translation, posttranslational modification, nuclear translocation of transcription factor, and its binding to ARE-driven gene promoters. This review summarizes current conceptions of Nrf2/Keap1/ARE induction and inactivation.
Nrf2 调节其启动子中含有抗氧化反应元件 (ARE) 的基因的表达，在所有氧化还原敏感转录因子中起着关键作用。Nrf2 受抑制蛋白 Keap1 的组成性控制，后者作为细胞内稳态紊乱的分子传感器。这些分子模式紧密相连，作为整合的氧化还原敏感信号系统 Nrf2/Keap1/ARE 的一部分发挥作用。根据细胞内氧化还原平衡的变化，该信号系统的活性在转录、翻译、翻译后修饰、转录因子的核易位以及其与 ARE 驱动的基因启动子的结合等水平上发生变化。这篇综述总结了 Nrf2/Keap1/ARE 的诱导和失活的最新概念。
