菁染料作为光动力反应中的高效光敏剂：光物理性质和体外光动力活性。
Cyanines as efficient photosensitizers in photodynamic reaction: photophysical properties and in vitro photodynamic activity.
机构信息
Medical University, Department of Medical Biochemistry, Wroclaw, Poland.
出版信息
Biochemistry (Mosc). 2011 Apr;76(4):473-9. doi: 10.1134/s0006297911040110.
The purpose of the present study was to explore the potential application of cyanines in photodynamic treatment. The photophysical features of four cyanines (KF570, HM118, FBF-749, and ER-139) were investigated by elemental and spectral analyses. Two malignant cell lines (MCF-7/WT and MCF-7/DOX) were used to test the potential for use in the photodynamic therapy. The cytotoxic effects of these dyes were determined by the MTT assay after 4 and 24 h of incubation with the cyanine. KF570 and HM118 were irradiated with red light (630-nm filter) and FBF-749 and ER-139 with green light (435-nm filter). The results showed that the cyanine HM118 demonstrated a major phototoxic effect. It was also noted that the efficiency of photodynamic therapy was higher in the doxorubicin-resistant cell line (MCF-7/DOX).
本研究旨在探讨花青染料在光动力治疗中的潜在应用。通过元素分析和光谱分析，研究了四种花青染料（KF570、HM118、FBF-749 和 ER-139）的光物理特性。使用两种恶性细胞系（MCF-7/WT 和 MCF-7/DOX）测试这些染料在光动力治疗中的应用潜力。在与花青孵育 4 和 24 小时后，通过 MTT 测定法确定这些染料的细胞毒性作用。KF570 和 HM118 用红光（630nm 滤光片）照射，而 FBF-749 和 ER-139 用绿光（435nm 滤光片）照射。结果表明，花青 HM118 表现出主要的光毒性作用。还注意到，在多柔比星耐药细胞系（MCF-7/DOX）中，光动力治疗的效率更高。
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