Graduate School of Arts and Sciences, University of Tokyo, 3-8-1 Komaba, Meguro-ku, Tokyo, Japan.
Dev Growth Differ. 2011 May;53(4):503-17. doi: 10.1111/j.1440-169X.2011.01266.x.
From hormonal secretion to gene expression, multicellular dynamics are rich in oscillatory regulation. When organized in space and time, periodic cell-cell signaling can give rise to long-range coordination of gene expression and cell movement in tissues. Lack of synchrony of the oscillations on the other hand can serve as a source of initial divergence of cell fate in stem cells. How properties of individual cells can account for collective rhythmic behaviors at the tissue level remains elusive in most cases. Recently, studies in chemical reactions, synthetic gene circuits, yeast and social amoeba Dictyostelium have greatly enhanced our view of collective oscillations in cell populations. From these relatively simple systems, a unified view of how excitable and oscillatory regulations could be tuned and coupled to give rise to tissue-level oscillations is emerging. The review focuses on recent progress in cyclic adenosine monophosphate oscillations in Dictyostelium and highlights similarities and differences with other systems. We will see that the autonomy of single-cell level oscillations and different ways in which cells are coupled influence how group-level information can be encoded in collective oscillations.
从激素分泌到基因表达，多细胞动力学充满了振荡调节。当细胞在空间和时间上被组织起来时，周期性的细胞间信号可以导致组织中基因表达和细胞运动的长程协调。另一方面，振荡的不同步可以作为干细胞中细胞命运初始分歧的来源。在大多数情况下，个体细胞的特性如何能够解释组织水平的集体节律行为仍然难以捉摸。最近，化学反应、合成基因电路、酵母和社会性阿米巴 Dictyostelium 的研究极大地增强了我们对细胞群体集体振荡的认识。从这些相对简单的系统中，出现了一种关于兴奋性和振荡调节如何被调整和耦合以产生组织水平振荡的统一观点。这篇综述重点介绍了 Dictyostelium 中环腺苷酸振荡的最新进展，并强调了与其他系统的相似性和差异性。我们将看到，单细胞水平振荡的自主性以及细胞耦合的不同方式会影响如何在集体振荡中编码群体水平的信息。
