从皮肤到疾病治疗——iPS 细胞研究在皮肤病学中的可能性。
From skin to the treatment of diseases--the possibilities of iPS cell research in dermatology.
机构信息
Department of Dermatology, Venereology and Allergology, University Medical Center Mannheim, Ruprecht-Karl University of Heidelberg, Mannheim, Germany.
出版信息
Exp Dermatol. 2011 Jun;20(6):523-8. doi: 10.1111/j.1600-0625.2011.01282.x.
Induced pluripotent stem cells (iPSCs) can be generated from different somatic cell types through ectopic expression of a set of transcription factors. iPSCs acquire all the features of embryonic stem cells (ESCs) including pluripotency and can thus give rise to any cell type of the body. iPSCs comparable with ESCs are amenable for the correction of gene mutations by homologous recombination. Patient-derived iPSCs may thus be an ideal source for studying diseases in vitro and for treating different disorders in the clinic. In this review, we summarize recent advances and possibilities of iPSC research with focus on the field of dermatology.
诱导多能干细胞（iPSCs）可以通过异位表达一组转录因子从不同的体细胞类型中产生。iPSCs 获得了胚胎干细胞（ESCs）的所有特征，包括多能性，因此可以产生身体的任何细胞类型。与 ESCs 相当的 iPSCs 可通过同源重组进行基因突变的校正。因此，患者来源的 iPSCs 可能是研究体外疾病和临床治疗不同疾病的理想来源。在这篇综述中，我们总结了 iPSC 研究的最新进展和可能性，重点是皮肤科领域。
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