p-loci：一个用于选择最有效亲权鉴定基因座集的计算机程序。

p-loci: a computer program for choosing the most efficient set of loci for parentage assignment.

机构信息

Department of Animal Sciences, Oregon State University, 2030 SE Marine Science Drive, Newport, OR 97365-5229, USA, Shellfish Genetics Program, USDA Agricultural Research Service, 2030 SE Marine Science Drive, Newport, OR 97365-5229, USA Department of Fisheries and Wildlife, Coastal Oregon Marine Experiment Station, Oregon State University, 2030 SE Marine Science Drive, Newport, OR 97365-5229, USA.

出版信息

Mol Ecol Resour. 2008 Jul;8(4):765-8. doi: 10.1111/j.1755-0998.2008.02128.x.

DOI:10.1111/j.1755-0998.2008.02128.x

PMID:21585886

Abstract

Determining how many and which codominant marker loci are required for accurate parentage assignment is not straightforward because levels of marker polymorphism, linkage, allelic distributions among potential parents and other factors produce differences in the discriminatory power of individual markers and sets of markers. p-loci software identifies the most efficient set of codominant markers for assigning parentage at a user-defined level of success, using either simulated or actual offspring genotypes of known parentage. Simulations can incorporate linkage among markers, mating design and frequencies of null alleles and/or genotyping errors. p-loci is available for windows systems at http://marineresearch.oregonstate.edu/genetics/ploci.htm.

摘要

确定需要多少个和哪些共显性标记位点才能准确进行亲子关系鉴定并不简单，因为标记多态性水平、连锁、潜在亲本等位基因分布以及其他因素会导致单个标记和标记集合的辨别力产生差异。p-loci 软件使用已知亲子关系的模拟或实际后代基因型，在用户定义的成功水平上确定分配亲子关系的最有效共显性标记集。模拟可以结合标记之间的连锁、交配设计以及无效等位基因和/或基因分型错误的频率。p-loci 可在 http://marineresearch.oregonstate.edu/genetics/ploci.htm 网站的 windows 系统上使用。