Regional MS Centre East-Brabant, Department of Neurology, Catharina Hospital, Eindhoven, The Netherlands.
Mult Scler. 2011 Sep;17(9):1146-8. doi: 10.1177/1352458511408476. Epub 2011 May 17.
Cardiovascular autonomic dysfunction is not uncommon in multiple sclerosis (MS) and is related to the involvement of the vegetative areas of cardiac innervations in the medulla oblongata. It has been suggested that this may contribute to the occurrence of sudden death in MS. In this case report, we present a patient with active relapsing-remitting MS who died unexpectedly due to the sudden onset of cardiac arrythmias. Post-mortem examination showed the presence of active demyelinating lesions in the medulla oblongata. As far as we know, this is the first case report clearly linking sudden cardiac death to active MS on the histopathological level.
心血管自主神经功能障碍在多发性硬化症（MS）中并不罕见，与延髓心脏传入神经的植物区受累有关。有人认为，这可能导致 MS 患者猝死。在本病例报告中，我们介绍了一位活动期复发缓解型 MS 患者，因心律失常突然意外死亡。尸检显示延髓有活跃的脱髓鞘病变。据我们所知，这是首例明确将心脏性猝死与组织病理学水平上的活动型 MS 联系起来的病例报告。
