Sparenberg A, Ernst H
Abteilung Strahlentherapie, Universitätsklinikum Steglitz der Freien Universität Berlin.
Strahlenther Onkol. 1990 Apr;166(4):251-5.
Since 1985, inoperable brain tumors, astrocytoma III or glioblastoma multiforme, have been treated by means of fractionated afterloading therapy combines with subsequent percutaneous irradiation. A screw that was specifically designed, allowed us to fix a precious metal tube to the skull cap for about eight days making possible the application of a marginal tumor dose of 30 Gy at a daily fractionation of 2 X 2 Gy using the iridium-afterloading-technique. Percutaneous saturation with another 30-40 Gy followed. Supported by radiobiological considerations, fractionation also appears to have a favorable influence on the perifocal edema formation in the brachytherapy of malignant brain tumors. After an observation period of four years probabilities of survival amounting to six months and twelve months can be calculated (according to Kaplan-Meier) for 68% and 27% of the total collective, respectively (n = 38). The survival rate for patients without pretreatment (n = 16) was 81% and 41% after six and twelve months respectively.
自1985年以来，无法手术的脑肿瘤，即III级星形细胞瘤或多形性胶质母细胞瘤，一直采用分次后装治疗结合后续经皮照射的方法进行治疗。一种专门设计的螺钉使我们能够将一根贵金属管固定在颅骨上约八天，从而可以使用铱后装技术，以2×2Gy的每日分次剂量施加30Gy的肿瘤边缘剂量。随后进行另外30 - 40Gy的经皮饱和照射。基于放射生物学考虑，分次照射似乎对恶性脑肿瘤近距离治疗中的瘤周水肿形成也有有利影响。经过四年的观察期，可以计算出（根据Kaplan - Meier法），在整个群体中，分别有68%和27%的患者存活六个月和十二个月的概率（n = 38）。未经预处理的患者（n = 16）在六个月和十二个月后的生存率分别为81%和41%。
