Fukumoto Ryo, Katayama Kinzo, Hayashi Tetsuya, Matsuoka Akira, Fujimoto Nobumasa, Koide Takuo, Kashiwagi Hiroko, Tagawa Tetsuzou, Onodera Takashi, Ishida Mitsuru
The Department of Urology, Osaka Kouseinennkin Hospital.
Hinyokika Kiyo. 2011 Mar;57(3):125-8.
Topiramate is an antiepileptic medicine that has been used adjunctively in the treatment of refractory seizures in Japan since 2007. Topiramate has been shown to inhibit specific carbonic anhydrase activity in the kidney and may induce a distal type of renal tubular acidosis. Case 1 : A 22-year-old male was referred to our hospital after complaining of left flank pain. He developed a seizure disorder and had been using topiramate for 4 months. Drip infusion pyelography showed a left ureteral stone. Case 2 : A 7-year-old boy presented with gross hematuria. He developed West syndrome and had been using topiramate for 6 months. A computed tomographic scan showed a right kidney stone.
托吡酯是一种抗癫痫药物，自2007年起在日本被用作难治性癫痫发作治疗的辅助药物。托吡酯已被证明可抑制肾脏中的特定碳酸酐酶活性，并可能诱发远端型肾小管酸中毒。病例1：一名22岁男性在抱怨左侧腰痛后被转诊至我院。他患有癫痫症，使用托吡酯已有4个月。静脉肾盂造影显示左侧输尿管结石。病例2：一名7岁男孩出现肉眼血尿。他患有韦斯特综合征，使用托吡酯已有6个月。计算机断层扫描显示右侧肾结石。
