Center for Molecular Protein Science, Biochemistry and Biophysical Chemistry, Lund University, Lund, Sweden.
Plant Signal Behav. 2011 Jun;6(6):905-10. doi: 10.4161/psb.6.6.15339. Epub 2011 Jun 1.
The ER chaperone calreticulin plays vital roles in numerous cellular processes, including Ca2+-homeostasis, apoptosis, and cell adhesion, in animal cells. Although calreticulin has been systematically characterized in animal cells, the focus has been on one of the isoforms. However, recent advances in the plant calreticulin field have revealed functional divergence of calreticulin isoforms. While two of the plant isoforms appear to work within a general ER chaperone framework, the third isoform is associated with folding of receptors for brassinosteroids and bacterial peptides. Hence, the discovery of functional specialization of plant calreticulins opens up new vistas for calreticulins also in the animal field.
内质网伴侣蛋白 calreticulin 在动物细胞的许多细胞过程中发挥着重要作用，包括 Ca2+稳态、细胞凋亡和细胞黏附。尽管 calreticulin 在动物细胞中已经被系统地进行了特征描述，但研究重点主要集中在其中一种同工型上。然而，植物 calreticulin 领域的最新进展揭示了 calreticulin 同工型的功能分化。虽然两种植物同工型似乎在一般的内质网伴侣蛋白框架内发挥作用，但第三种同工型与植物固醇和细菌肽受体的折叠有关。因此，植物 calreticulin 功能特化的发现为动物领域的 calreticulin 开辟了新的前景。
