Silvano S, Elia C, Alessandria C, Bruno M, Musso A, Saracco G, Rizzetto M, Venon W Debernardi
Gastro-Hepatology Unit, San Giovanni Battista Hospital, University of Turin, Turin, Italy.
Minerva Gastroenterol Dietol. 2011 Jun;57(2):111-5.
Endoscopic variceal ligation (EVL) is recommended for the treatment of esophageal variceal bleeding. The aim of this study was to assess the most cost-effective timing of endoscopic follow-up after variceal eradication.
Cirrhotics with esophageal varices treated between January 2008 and January 2009 until reached variceal obliteration were retrospectively analyzed for technical aspects and for outcomes.
Out of 127 patients treated with EVL, 103 were included. Number of sessions to achieve variceal obliteration and number of bands for each session were 2.8±1.3 (range 1-7) and 4.6±1 (range 2-7), respectively. The placement of >5 bands per session was not associated with higher incidence of complications (19.6% vs. 17.8%, P=ns). Esophageal ulcers were observed in 42% of patients when the interbanding interval was <20 days (versus 15% for interval >20 days, P<0.05). Once obliteration was achieved, varices reappeared in 28% of patients; the early appearance of small varices was not associated with bleeding.
A longer interbanding interval reduces the incidence of procedural-related complications. After variceal obliteration an early endoscopic control is not useful because it does not influence the approach and does not change the patient outcome.
内镜下静脉曲张结扎术(EVL)被推荐用于治疗食管静脉曲张破裂出血。本研究的目的是评估静脉曲张根除术后内镜随访的最具成本效益的时机。
回顾性分析2008年1月至2009年1月间接受治疗直至静脉曲张消失的食管静脉曲张肝硬化患者的技术方面和治疗结果。
在127例行EVL治疗的患者中,103例被纳入研究。实现静脉曲张消失的疗程数和每个疗程的结扎带数量分别为2.8±1.3(范围1 - 7)和4.6±1(范围2 - 7)。每个疗程放置>5条结扎带与更高的并发症发生率无关(19.6%对17.8%,P =无显著性差异)。当结扎间隔<20天时,42%的患者出现食管溃疡(间隔>20天时为15%,P<0.05)。一旦实现消失,28%的患者静脉曲张复发;小静脉曲张的早期出现与出血无关。
更长的结扎间隔可降低与手术相关的并发症发生率。静脉曲张消失后早期内镜检查无用,因为它不影响治疗方法且不改变患者预后。