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1-乙酰基-3-[2-(2,3,5,6-四氟苯基)肼-1-亚基]吲哚啉-2-酮

1-Acetyl-3-[2-(2,3,5,6-tetra-fluoro-phen-yl)hydrazin-1-yl-idene]indolin-2-one.

作者信息

Pervez Humayun, Yaqub Muhammad, Ahmad Maqbool, Tahir M Nawaz, Akhtar Robina

出版信息

Acta Crystallogr Sect E Struct Rep Online. 2010 Jun 16;66(Pt 7):o1686. doi: 10.1107/S1600536810022580.

DOI:10.1107/S1600536810022580
PMID:21587910
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3006959/
Abstract

In the title compound, C(16)H(9)F(4)N(3)O(2), the dihedral angle between the aromatic ring systems is 4.10 (14)° and a bifurcated intra-molecular N-H⋯(O,F) hydrogen bond generates an S(6) ring for the O-atom acceptor and an S(5) ring for the F-atom acceptor. A short C-H⋯O conact also occurs. In the crystal, mol-ecules are linked by C-H⋯O inter-actions.

摘要

在标题化合物C₁₆H₉F₄N₃O₂中，芳环系统之间的二面角为4.10 (14)°，一个分叉的分子内N-H⋯(O,F)氢键为氧原子受体生成一个S(6)环，为氟原子受体生成一个S(5)环。还存在一个短的C-H⋯O接触。在晶体中，分子通过C-H⋯O相互作用连接。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6445/3006959/52e9a2f32b40/e-66-o1686-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6445/3006959/6662461502d2/e-66-o1686-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6445/3006959/52e9a2f32b40/e-66-o1686-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6445/3006959/6662461502d2/e-66-o1686-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6445/3006959/52e9a2f32b40/e-66-o1686-fig2.jpg

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本文引用的文献

1
4-(2-Fluoro-phen-yl)-1-(2-oxoindolin-3-yl-idene)thio-semicarbazide.4-（2-氟苯基）-1-（2-氧代吲哚啉-3-亚基）硫代氨基脲
Acta Crystallogr Sect E Struct Rep Online. 2010 Apr 2;66(Pt 5):o1018. doi: 10.1107/S1600536810011682.
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Structure validation in chemical crystallography.化学晶体学中的结构验证
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In vitro cytotoxic, antibacterial, antifungal and urease inhibitory activities of some N4- substituted isatin-3-thiosemicarbazones.
某些N4-取代异吲哚-3-硫代半卡巴腙的体外细胞毒性、抗菌、抗真菌和脲酶抑制活性
J Enzyme Inhib Med Chem. 2008 Dec;23(6):848-54. doi: 10.1080/14756360701746179.
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A short history of SHELX.SHELX简史。
Acta Crystallogr A. 2008 Jan;64(Pt 1):112-22. doi: 10.1107/S0108767307043930. Epub 2007 Dec 21.
5
Synthesis of some N4-substituted isatin-3-thiosemicarbazones.一些N4-取代异吲哚-3-硫代半卡巴腙的合成。
Nat Prod Res. 2007 Nov;21(13):1178-86. doi: 10.1080/14786410601129770.