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2-氯-7-甲基-12-苯基二苯并[b,g][1,8]萘啶-11(6H)-酮

2-Chloro-7-methyl-12-phenyldibenzo[b,g][1,8]naphthyridin-11(6H)-one.

作者信息

Vennila K N, Prabha K, Manoj M, Prasad K J Rajendra, Velmurugan D

出版信息

Acta Crystallogr Sect E Struct Rep Online. 2010 Jun 26;66(Pt 7):o1823. doi: 10.1107/S160053681002430X.

DOI:10.1107/S160053681002430X
PMID:21588030
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3007064/
Abstract

In the title compound, C(23)H(15)ClN(2)O, the fused ring system is planar: the deviation of all the non-H atoms from the plane through all four fused rings is less than 0.31 Å. The plane of the phenyl ring is inclined at 71.78 (5)° to the mean plane of the 1,8-naphthrydine ring system. The crystal structure is devoid of any classical hydrogen bonds but π-π inter-actions are present.

摘要

在标题化合物C₂₃H₁₅ClN₂O中，稠环体系是平面的：所有非氢原子相对于通过所有四个稠环的平面的偏差小于0.31 Å。苯环平面与1,8-萘啶环体系的平均平面倾斜71.78 (5)°。晶体结构中不存在任何经典氢键，但存在π-π相互作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d0e1/3007064/20b44fb956e8/e-66-o1823-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d0e1/3007064/8f032ad6a003/e-66-o1823-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d0e1/3007064/20b44fb956e8/e-66-o1823-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d0e1/3007064/8f032ad6a003/e-66-o1823-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d0e1/3007064/20b44fb956e8/e-66-o1823-fig2.jpg

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本文引用的文献

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2
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3
Microwave-induced synthesis and anti-microbial activities of 7,10,11,12-tetrahydrobenzo[c]acridin-8(9H)-one derivatives.
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4
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Acta Crystallogr A. 2008 Jan;64(Pt 1):112-22. doi: 10.1107/S0108767307043930. Epub 2007 Dec 21.
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9
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