降钙素基因相关肽（CGRP）治疗对发育不全肌管正常超微结构的诱导作用。
Induction of normal ultrastructure by CGRP treatment in dysgenic myotubes.
作者信息
Garcia L, Pinçon-Raymond M, Romey G, Changeux J P, Lazdunski M, Rieger F
机构信息
Groupe de Biologie et Pathologie neuromusculaires, U.153 INSERM, Paris, France.
出版信息
FEBS Lett. 1990 Apr 9;263(1):147-52. doi: 10.1016/0014-5793(90)80725-x.
The calcitonin gene-related peptide (CGRP) restores an apparent normal ultrastructure in mdg/mdg muscle cells in vitro, including a normal triadic organization which is known to be essential for excitation-contraction (E-C) coupling. However, neither slow L-type Ca2+ channel activity nor E-C coupling, which are absent in mdg/mdg muscle, were re-established. These observations suggest a potential role of CGRP (and also of cAMP as the intracellular messenger) in the morphological development of the muscle fiber.
降钙素基因相关肽（CGRP）在体外可使mdg/mdg肌肉细胞的超微结构恢复至明显正常的状态，包括正常的三联体结构，而三联体结构已知对兴奋-收缩（E-C）偶联至关重要。然而，mdg/mdg肌肉中原本缺失的慢L型Ca2+通道活性和E-C偶联均未得到恢复。这些观察结果表明，CGRP（以及作为细胞内信使的cAMP）在肌纤维的形态发育中可能发挥作用。
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