• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

（E）-N'-（3,3-二甲基-2,6-二苯基哌啶-4-亚基）异烟酰肼

(E)-N'-(3,3-Dimethyl-2,6-diphenyl-piperidin-4-yl-idene)isonicotinohydrazide.

作者信息

Sankar C, Pandiarajan K, Thiruvalluvar A, Gayathri P

出版信息

Acta Crystallogr Sect E Struct Rep Online. 2010 Oct 20;66(Pt 11):o2841. doi: 10.1107/S1600536810040936.

DOI:10.1107/S1600536810040936
PMID:21589027
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3009086/
Abstract

In the title mol-ecule, C(25)H(26)N(4)O, the piperidine ring adopts a chair conformation, with the plane through the four coplanar atoms making dihedral angles of 84.76 (6), 82.28 (5) and 81.91 (6)° with the pyridine-ring and the phenyl rings at the 2 and 6 positions, respectively. The pyridine ring makes dihedral angles of 64.13 (8) and 10.75 (8)° with the phenyl rings at the 2 and 6 positions, respectively. The dihedral angle between the two phenyl rings is 53.57 (8)°. The phenyl rings and one of the methyl groups at position 3 have an equatorial orientation. In the crystal, mol-ecules are linked by N-H⋯O and C-H⋯O hydrogen bonds.

摘要

在标题分子C(25)H(26)N(4)O中，哌啶环呈椅式构象，通过四个共面原子的平面与吡啶环以及2和6位的苯环分别形成84.76 (6)、82.28 (5)和81.91 (6)°的二面角。吡啶环与2和6位的苯环分别形成64.13 (8)和10.75 (8)°的二面角。两个苯环之间的二面角为53.57 (8)°。苯环和3位的一个甲基具有平伏取向。在晶体中，分子通过N-H⋯O和C-H⋯O氢键相连。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8520/3009086/4946bd6581e2/e-66-o2841-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8520/3009086/41a05cd1304c/e-66-o2841-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8520/3009086/4946bd6581e2/e-66-o2841-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8520/3009086/41a05cd1304c/e-66-o2841-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8520/3009086/4946bd6581e2/e-66-o2841-fig2.jpg

相似文献

1
(E)-N'-(3,3-Dimethyl-2,6-diphenyl-piperidin-4-yl-idene)isonicotinohydrazide.（E）-N'-（3,3-二甲基-2,6-二苯基哌啶-4-亚基）异烟酰肼
Acta Crystallogr Sect E Struct Rep Online. 2010 Oct 20;66(Pt 11):o2841. doi: 10.1107/S1600536810040936.
2
(1-Acetyl-2,6-diphenyl-piperidin-4-yl-idene)(phen-yl)acetonitrile.（1-乙酰基-2,6-二苯基-哌啶-4-亚基）（苯基）乙腈
Acta Crystallogr Sect E Struct Rep Online. 2008 Apr 4;64(Pt 5):o797. doi: 10.1107/S160053680800860X.
3
t-3-Benzyl-r-2,c-6-bis-(4-methoxy-phen-yl)piperidin-4-one oxime.t-3-苄基-r-2,c-6-双-(4-甲氧基-苯基)哌啶-4-酮肟
Acta Crystallogr Sect E Struct Rep Online. 2008 Jun 7;64(Pt 7):o1211. doi: 10.1107/S1600536808016449.
4
Crystal structures of (E)-(3-ethyl-1-methyl-2,6-di-phenyl-piperidin-4-yl-idene)amino phenyl carbonate and (E)-(3-isopropyl-1-methyl-2,6-di-phenyl-piperidin-4-yl-idene)amino phenyl carbonate.（E）-（3-乙基-1-甲基-2,6-二苯基-哌啶-4-亚基）氨基苯基碳酸酯和（E）-（3-异丙基-1-甲基-2,6-二苯基-哌啶-4-亚基）氨基苯基碳酸酯的晶体结构
Acta Crystallogr Sect E Struct Rep Online. 2014 Sep 13;70(Pt 10):199-202. doi: 10.1107/S1600536814018893. eCollection 2014 Oct 1.
5
t-3-Benzyl-r-2,c-6-bis-(4-methoxy-phen-yl)-piperidin-4-one.t-3-苄基-r-2，c-6-双-（4-甲氧基-苯基）-哌啶-4-酮
Acta Crystallogr Sect E Struct Rep Online. 2008 Jun 7;64(Pt 7):o1181. doi: 10.1107/S1600536808015717.
6
(E)-N'-(2,4,5-Trimethoxy-benzyl-idene)isonicotinohydrazide dihydrate.（E）-N'-（2,4,5-三甲氧基-亚苄基）异烟酰肼二水合物
Acta Crystallogr Sect E Struct Rep Online. 2010 Apr 30;66(Pt 5):o1235-6. doi: 10.1107/S1600536810015254.
7
t-3-Pentyl-r-2,c-6-diphenyl-piperidin-4-one.t-3-戊基-r-2，c-6-二苯基-哌啶-4-酮
Acta Crystallogr Sect E Struct Rep Online. 2009 Nov 14;65(Pt 12):o3083. doi: 10.1107/S1600536809046753.
8
(E)-N'-(2,4,5-Trifluorobenzyl-idene)isonicotinohydrazide monohydrate.（E）-N'-（2,4,5-三氟亚苄基）异烟酰肼一水合物
Acta Crystallogr Sect E Struct Rep Online. 2010 Feb 10;66(Pt 3):o579. doi: 10.1107/S1600536810004514.
9
(4E)-N-[(2-Bromo-phen-yl)meth-oxy]-1,3-dimethyl-2,6-diphenyl-piperidin-4-imine.(4E)-N-[(2-溴苯基)甲氧基]-1,3-二甲基-2,6-二苯基哌啶-4-亚胺
Acta Crystallogr Sect E Struct Rep Online. 2012 Jul 1;68(Pt 7):o2267. doi: 10.1107/S1600536812028887. Epub 2012 Jun 30.
10
Redetermination of loperamide monohydrate.洛哌丁胺一水合物的重新测定。
Acta Crystallogr Sect E Struct Rep Online. 2012 Feb 1;68(Pt 2):o539-40. doi: 10.1107/S1600536812003091. Epub 2012 Jan 31.

引用本文的文献

1
N'-(Adamantan-2-yl-idene)benzo-hydrazide.N'-(金刚烷-2-亚基)苯甲酰肼
Acta Crystallogr Sect E Struct Rep Online. 2012 Jul 1;68(Pt 7):o2247-8. doi: 10.1107/S1600536812028644. Epub 2012 Jun 30.

本文引用的文献

1
Preparation and antitubercular activities in vitro and in vivo of novel Schiff bases of isoniazid.异烟肼新型席夫碱的制备及其体外和体内抗结核活性
Eur J Med Chem. 2009 Oct;44(10):4169-78. doi: 10.1016/j.ejmech.2009.05.009. Epub 2009 May 21.
2
Structure validation in chemical crystallography.化学晶体学中的结构验证
Acta Crystallogr D Biol Crystallogr. 2009 Feb;65(Pt 2):148-55. doi: 10.1107/S090744490804362X. Epub 2009 Jan 20.
3
A short history of SHELX.SHELX简史。
Acta Crystallogr A. 2008 Jan;64(Pt 1):112-22. doi: 10.1107/S0108767307043930. Epub 2007 Dec 21.
4
1-N-(Arylmaleamoyl)-3,5-bis(phenylmethylene)4-piperidones: a novel class of antimycobacterial agents.1-N-（芳基马来酰基）-3,5-双（苯亚甲基）-4-哌啶酮：一类新型抗分枝杆菌药物。
Pharmazie. 2006 Jun;61(6):562-3.
5
Synthesis, stereochemistry, and antimicrobial activity of 2,6-diaryl-3-(arylthio)piperidin-4-ones.2,6-二芳基-3-(芳硫基)哌啶-4-酮的合成、立体化学及抗菌活性
Chem Pharm Bull (Tokyo). 2006 Jun;54(6):795-801. doi: 10.1248/cpb.54.795.
6
In vitro and in vivo activities of acylated derivatives of isoniazid against mycobacterium tuberculosis.异烟肼酰化衍生物对结核分枝杆菌的体外和体内活性
Drug Des Discov. 2003;18(4):103-8.