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(2R,4R)-1-(叔丁氧羰基)-4-甲氧基吡咯烷-2-羧酸

(2R,4R)-1-(tert-But-oxy-carbon-yl)-4-meth-oxy-pyrrolidine-2-carb-oxy-lic acid.

作者信息

Yuan Jing, Cai Zhi-Qiang, Huang Chang-Jiang, Xu Wei-Ren

出版信息

Acta Crystallogr Sect E Struct Rep Online. 2010 Nov 20;66(Pt 12):o3258. doi: 10.1107/S1600536810047707.

DOI:10.1107/S1600536810047707
PMID:21589542
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3011444/
Abstract

In the title compound, C(11)H(19)NO(5), the five-membered pyrrolidine ring adopts an envelope conformation. The dihedral angles between the carboxyl group plane, the pyrrolidine ring and the meth-oxy group are 59.50 (3) and 62.02 (1)°, respectively. In the crystal, inter-molecular O-H⋯O hydrogen bonds link the mol-ecules into chains along [100]. The absolute configuration is assigned in accord with that of (2R,4R)-1-(tert-but-oxy-carbon-yl)-4-hy-droxy-pyrrolidine-2-carb-oxy-lic acid, which was the starting material in the synthesis.

摘要

在标题化合物C(11)H(19)NO(5)中，五元吡咯烷环呈信封式构象。羧基平面、吡咯烷环和甲氧基之间的二面角分别为59.50 (3)°和62.02 (1)°。在晶体中，分子间的O-H⋯O氢键将分子沿[100]方向连接成链。绝对构型根据合成起始原料(2R,4R)-1-(叔丁氧基羰基)-4-羟基吡咯烷-2-羧酸的构型确定。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/71c6/3011444/26c7317d9303/e-66-o3258-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/71c6/3011444/26c7317d9303/e-66-o3258-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/71c6/3011444/26c7317d9303/e-66-o3258-fig1.jpg

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