Chen H, Udelsman R, Zeiger M, Ball D
JOHNS HOPKINS MED INST,CTR ONCOL,BALTIMORE,MD 21231. JOHNS HOPKINS MED INST,DIV ENDOCRINE & ONCOL SURG,BALTIMORE,MD 21231. JOHNS HOPKINS MED INST,DIV ENDOCRINOL & METAB,BALTIMORE,MD 21231.
Oncol Rep. 1997 Jul-Aug;4(4):775-8. doi: 10.3892/or.4.4.775.
Human achaete-scute homolog-1 (hASH1) is critical for establishing the neuroendocrine (NE) phenotype of small cell lung cancer. To define its role in other neoplasms, we analyzed 33 tumors for hASH1 by Northern blotting. Significant levels of hASH1 mRNA were detected in 4 pheochromocytomas, 2 medullary thyroid cancers, and 1 thymic carcinoid. hASH1 transcripts were undetectable in 8 parathyroid lesions, 6 gastrinomas, 4 insulinomas, and 7 thyroid neoplasms, as well as in normal thyroid, adrenal, or pancreas tissue. Therefore, hASH1 mRNA is highly abundant in a subset of human tumors and may play a role in dictating their NE phenotype.
人类无翅型MMTV整合位点家族成员1（hASH1）对于确立小细胞肺癌的神经内分泌（NE）表型至关重要。为了明确其在其他肿瘤中的作用，我们通过Northern印迹法分析了33个肿瘤中的hASH1。在4例嗜铬细胞瘤、2例甲状腺髓样癌和1例胸腺类癌中检测到显著水平的hASH1 mRNA。在8例甲状旁腺病变、6例胃泌素瘤、4例胰岛素瘤、7例甲状腺肿瘤以及正常甲状腺、肾上腺或胰腺组织中未检测到hASH1转录本。因此，hASH1 mRNA在一部分人类肿瘤中高度丰富，可能在决定其NE表型中发挥作用。
