Department of Orthopaedics and Rehabilitation, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Portland, Oregon 97201, USA.
J Orthop Res. 2011 Dec;29(12):1840-5. doi: 10.1002/jor.21459. Epub 2011 May 16.
Structural femoral ring allograft is commonly used in interbody spinal arthrodesis. Fractures of implanted femoral ring allograft have been reported. Data to guide donor screening and tissue processing by allograft tissue banks for factors that affect graft strength are incomplete. Fresh frozen human femora from 34 cadaveric donors were sectioned into ten 20-mm thick specimens. Bone mineral density (BMD), donor age, and graft dimensions were recorded for each specimen. Three hundred twenty-seven specimens were tested in quasi-static axial compression. Linear regression models compared load to failure with BMD, sex-specific donor age, minimum/maximum cortical wall thickness, and minimum/maximum outer ring diameter. Correlations between minimum and maximum cortical wall thickness and load to failure were significant (r = 0.73, p < 0.001 and r = 0.74, p < 0.001, respectively). BMD showed a weaker negative correlation with load to failure (r = -0.11, p = 0.05). Correlations between load to failure and minimum and maximum outer ring diameter and age (r = 0.06, p = 0.31) were not significant. We found that the minimum and maximum cortical wall thicknesses of femoral ring allograft are strongly correlated with the axial compressive load to failure of the graft. Other tested parameters did not prove to be effective predictors of resistance to axial loading.
结构性股骨环同种异体移植物常用于椎间融合术。已有报道称同种异体移植股骨环发生骨折。指导供体筛选和同种异体组织库进行组织处理的数据不完整，缺乏关于影响移植物强度的因素。从 34 具尸体供体中取出新鲜冷冻的人股骨，将其切成 10 个 20 毫米厚的标本。记录每个标本的骨矿物质密度（BMD）、供体年龄和移植物尺寸。对 327 个标本进行准静态轴向压缩测试。线性回归模型将破坏时的载荷与 BMD、性别特异性供体年龄、最小/最大皮质壁厚度以及最小/最大外环直径进行比较。最小和最大皮质壁厚度与破坏时载荷之间的相关性具有统计学意义（r=0.73，p<0.001 和 r=0.74，p<0.001）。BMD 与破坏时载荷之间呈较弱的负相关（r=-0.11，p=0.05）。破坏时载荷与最小和最大外环直径和年龄之间的相关性不显著（r=0.06，p=0.31）。我们发现，股骨环同种异体移植物的最小和最大皮质壁厚度与移植物的轴向压缩破坏载荷密切相关。其他测试参数不能证明是抵抗轴向加载的有效预测因子。
