选择性δ阿片受体激动剂美替法胺（LY127623）对胃功能的影响。

Effects of metkephamid (LY127623), a selective delta opioid receptor agonist, on gastric function.

作者信息

Glavin G B, Pinsky C, Hall A M

机构信息

Dept. of Surgery, Faculty of Medicine, University of Manitoba, Winnipeg, Canada.

出版信息

Life Sci. 1990;46(15):1075-9. doi: 10.1016/0024-3205(90)90416-o.

DOI:10.1016/0024-3205(90)90416-o

PMID:2159095

Abstract

Metkephamid, a delta opioid receptor agonist, blocked cold-restraint stress ulcers, reduced absolute ethanol-induced gastric ulcers and, at the lowest and highest doses examined, reduced basal gastric acid secretion in conscious rats, all to a significant degree. The dose effects on stress ulcer formation parallel those seen against maximal electroshock seizures and suggest that both central as well as peripheral delta opioid receptors mediate gastrointestinal responses to stress.

摘要

美他啡肽是一种δ阿片受体激动剂，可阻断冷束缚应激性溃疡，减轻无水乙醇诱导的胃溃疡，并且在所检测的最低和最高剂量下，能显著降低清醒大鼠的基础胃酸分泌。其对应激性溃疡形成的剂量效应与对最大电休克惊厥的效应相似，表明中枢和外周的δ阿片受体均介导胃肠道对应激的反应。