Wild Andreas, Hornig Stephanie, Schlütter Florian, Vitz Jürgen, Friebe Christian, Hager Martin D, Winter Andreas, Schubert Ulrich S
Laboratory of Organic and Macromolecular Chemistry, Friedrich-Schiller-University Jena, Humboldtstr.10, D-07743 Jena, Germany; Dutch Polymer Institute (DPI), P.O. Box 902, 5600 AX Eindhoven, The Netherlands.
Macromol Rapid Commun. 2010 May 12;31(9-10):921-7. doi: 10.1002/marc.201000010. Epub 2010 Apr 21.
Dextran was functionalized with 6-(2,2':6',2″-terpyridin-4'-yloxy)-hexanoic acid using two different ratios of terpyridine to dextran, leading to terpyridine-functionalized dextran esters possessing different degrees of substitution (DS = 0.23-0.41). The intra- and intermolecular complexation behavior of both functionalized biopolymers was studied using Fe(II) metal ions as well as activated Ru(III) complexes. The complexation behavior in the first case was studied by UV-visible and viscosity titration experiments. In the latter case, a water soluble comb-polymer could be obtained when using a PEG- functionalized terpyridine Ru(II) moiety for complexation. Moreover, nanoprecipitation was applied to self-assemble the functionalized dextrans into nanoparticles.
使用两种不同比例的三联吡啶与葡聚糖，将葡聚糖与6-(2,2':6',2″-三联吡啶-4'-氧基)-己酸进行功能化反应，得到具有不同取代度（DS = 0.23 - 0.41）的三联吡啶功能化葡聚糖酯。使用Fe(II)金属离子以及活化的Ru(III)配合物研究了两种功能化生物聚合物的分子内和分子间络合行为。第一种情况下的络合行为通过紫外可见光谱和粘度滴定实验进行研究。在后一种情况下，当使用聚乙二醇功能化的三联吡啶Ru(II)部分进行络合时，可以得到一种水溶性梳状聚合物。此外，采用纳米沉淀法将功能化葡聚糖自组装成纳米颗粒。
