Department of Physics and Medical Technology, VU University Medical Center, Amsterdam, The Netherlands.
J Magn Reson Imaging. 2011 Jun;33(6):1362-8. doi: 10.1002/jmri.22581.
To evaluate if early onset of retrograde flow in the main pulmonary artery is a characteristic of pulmonary arterial hypertension (PAH).
Fifty-five patients with suspected pulmonary hypertension (PH) underwent right-sided heart catheterization and retrospectively ECG-gated MR phase-contrast velocity quantification in the main pulmonary artery. Pulmonary hypertension was defined by a mean pulmonary artery pressure being larger than 25 mmHg. The onset time of the retrograde flow relative to the cardiac cycle duration (Relative Onset Time = ROT) was compared with mean pulmonary artery pressure.
By the catheterization, 38 patients were identified as having PAH. The ROT for these PAH patients was significantly different from those found in the 17 non-PH subjects (0.14 ± 0.06 versus 0.37 ± 0.06, P < 0.001). The mean pulmonary artery pressure was related to the ROT (r(2) = 0.62, P < 0.001) and could be estimated from the ROT with a standard deviation of 11.7 mmHg. With a cutoff value of 0.25, the ROT distinguished PAH patients from non-PH subjects.
Early onset of retrograde flow in the main pulmonary artery is a characteristic of pulmonary arterial hypertension and is visible by standard MR phase-contrast velocity quantification.
评估主肺动脉内逆行血流的早期出现是否是肺动脉高压（PAH）的特征。
55 例疑似肺动脉高压（PH）的患者接受了右侧心脏导管检查，并对主肺动脉进行了回顾性 ECG 门控 MR 相位对比速度定量。肺动脉高压的定义为平均肺动脉压大于 25mmHg。将逆行血流相对于心动周期持续时间的起始时间（相对起始时间=ROT）与平均肺动脉压进行比较。
通过导管检查，38 例患者被诊断为 PAH。这些 PAH 患者的 ROT 与 17 例非 PH 患者明显不同（0.14±0.06 对 0.37±0.06，P＜0.001）。平均肺动脉压与 ROT 相关（r²=0.62，P＜0.001），可以通过 ROT 以 11.7mmHg 的标准差进行估计。ROT 的截断值为 0.25，可以将 PAH 患者与非 PH 患者区分开来。
主肺动脉内逆行血流的早期出现是肺动脉高压的特征，可以通过标准的 MR 相位对比速度定量检测到。
