Rivkina M B, Tikhonenko T I
Mol Gen Mikrobiol Virusol. 1990 Feb(2):3-9.
Hepatitis B virus (HBV) is the causative agent of hepatocellular carcinoma (HCC) in man. The HBV genome is a circular partially double-stranded DNA molecule of about 3.2 kb. The HBV genome contains four structural genes coding for the HBV envelope (HBsAg) and core (HBcAg/HBeAg) proteins, endogenous DNA-polymerase with the additional enzymatic activity of a reverse transcriptase and polypeptide X functioning as a trans-activator of cellular and viral genes. HBV DNA integration in the genomes of HCCs and hepatocytes of HBV carriers is an important evidence establishing a relationship between the HBV infection and the development of HCC. The mechanism of HBV DNA integration into the cellular genome and the possible role of integrated HBV DNA sequences in the malignant transformation of hepatocytes are discussed.
乙型肝炎病毒（HBV）是人类肝细胞癌（HCC）的病原体。HBV基因组是一个约3.2kb的环状部分双链DNA分子。HBV基因组包含四个结构基因，分别编码HBV包膜（HBsAg）和核心（HBcAg/HBeAg）蛋白、具有逆转录酶额外酶活性的内源性DNA聚合酶以及作为细胞和病毒基因反式激活因子的多肽X。HBV DNA整合到HCC基因组以及HBV携带者的肝细胞基因组中，是确立HBV感染与HCC发生之间关系的重要证据。本文讨论了HBV DNA整合到细胞基因组的机制以及整合的HBV DNA序列在肝细胞恶性转化中的可能作用。
