Miyamoto Kazuyuki, Dohi Kenji
Department of Emergency and Critical Care Medicine, Showa University.
Nihon Rinsho. 2011 Apr;69(4):648-52.
Therapeutic mechanisms of hyperbaric oxygen therapy (HBOT) are based on elevation of both the partial pressure of oxygen and hydrostatic pressure. It has been reported that HBOT supply much amount of oxygen and might prevent from brain tissue after global ischemia in patients with post-cardiac arrest syndrome(PCAS). On the other hand, high levels of oxygen produce reactive oxygen species(ROS). ROS occurs secondary brain damage after ischemia. The clinical evidence of HBOT has not been established. In this paper, we review some reports about the advantages and disadvantages of HBOT after global ischemia with PCAS.
高压氧治疗(HBOT)的治疗机制基于氧分压和静水压力的升高。据报道,HBOT能提供大量氧气,可能预防心脏骤停后综合征(PCAS)患者全脑缺血后的脑组织损伤。另一方面,高浓度的氧气会产生活性氧(ROS)。ROS会在缺血后导致继发性脑损伤。HBOT的临床证据尚未确立。在本文中,我们回顾了一些关于PCAS患者全脑缺血后HBOT优缺点的报告。