Department of Organic Chemistry, University of Geneva 30, quai Ernest Ansermet CH-1211 Geneva 4, Switzerland.
Org Lett. 2011 Jun 17;13(12):3040-3. doi: 10.1021/ol200898c. Epub 2011 May 18.
Readily available alkenylalanes, arising from hydroalumination of unprotected terminal alkynes, have been directly employed for the copper-catalyzed asymmetric conjugate addition (ACA) to β-substituted cyclic enones. The desired products, containing a quaternary stereogenic center, are generally obtained in good yields and enantioselectivities.
readily available alkenylalanes, arising from hydroalumination of unprotected terminal alkynes, have been directly employed for the copper-catalyzed asymmetric conjugate addition (ACA) to β-substituted cyclic enones. The desired products, containing a quaternary stereogenic center, are generally obtained in good yields and enantioselectivities.
