新型串联氢铝化/Cu 催化不对称共轭加成β-取代环状烯酮的实验条件。
New experimental conditions for tandem hydroalumination/Cu-catalyzed asymmetric conjugate additions to β-substituted cyclic enones.
机构信息
Department of Organic Chemistry, University of Geneva 30, quai Ernest Ansermet CH-1211 Geneva 4, Switzerland.
出版信息
Org Lett. 2011 Jun 17;13(12):3040-3. doi: 10.1021/ol200898c. Epub 2011 May 18.
Readily available alkenylalanes, arising from hydroalumination of unprotected terminal alkynes, have been directly employed for the copper-catalyzed asymmetric conjugate addition (ACA) to β-substituted cyclic enones. The desired products, containing a quaternary stereogenic center, are generally obtained in good yields and enantioselectivities.
readily available alkenylalanes, arising from hydroalumination of unprotected terminal alkynes, have been directly employed for the copper-catalyzed asymmetric conjugate addition (ACA) to β-substituted cyclic enones. The desired products, containing a quaternary stereogenic center, are generally obtained in good yields and enantioselectivities.
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