School of Medicine, the University of Melbourne, Melbourne, Victoria, Australia.
J Gastroenterol Hepatol. 2011 Oct;26(10):1485-92. doi: 10.1111/j.1440-1746.2011.06768.x.
The importance of Barrett's esophagus (BE) lies in its potential to give rise to esophageal adenocarcinoma (EAC), postulated to be through a series of progressive degrees of dysplasia; from intestinal metaplasia to low-grade dysplasia, high-grade dysplasia, and subsequently, to cancer. The management strategies for the detection and treatment of dysplasia and early esophageal cancer on a background of BE have changed significantly in the last few decades, with the emergence of newer and less invasive non-operative alternatives. This review aims to outline BE and its relation to EAC, the rationale and cost-effectiveness of both screening and surveillance programs, methods of diagnosing and identifying dysplasia and early cancer in Barrett's, and approaches to individualizing their endoscopic and surgical management based on best-available staging techniques.
巴雷特食管（BE）的重要性在于其可能引发食管腺癌（EAC），据推测是通过一系列逐渐加重的异型增生程度；从肠上皮化生到低级别异型增生、高级别异型增生，然后发展为癌症。在过去几十年中，BE 背景下异型增生和早期食管癌的检测和治疗策略发生了显著变化，出现了更新、创伤更小的非手术替代方法。本综述旨在概述 BE 及其与 EAC 的关系、筛查和监测计划的原理和成本效益、诊断和识别 Barrett 中异型增生和早期癌症的方法，以及根据最佳现有分期技术个体化内镜和手术管理的方法。
