左乙拉西坦在伴有癫痫发作的新生儿中的药代动力学。
Pharmacokinetics of levetiracetam in neonates with seizures.
机构信息
Perinatal Institute, Division of Neonatology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.
出版信息
J Pediatr. 2011 Jul;159(1):152-154.e3. doi: 10.1016/j.jpeds.2011.03.057. Epub 2011 May 18.
Abstract
The pharmacokinetics of levetiracetam were determined prospectively in 18 neonates with seizures. Neonates were found to have lower clearance, higher volume of distribution, and a longer half-life as compared with older children and adults. Mild somnolence was the only adverse effect.
摘要
左乙拉西坦的药代动力学在 18 名患有癫痫的新生儿中进行了前瞻性研究。与年龄较大的儿童和成人相比，新生儿的清除率较低，分布容积较高，半衰期较长。唯一的不良反应是轻度嗜睡。
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