UCL, Department of Cancer Biology, University College London, Gower Street, London, UK.
Database (Oxford). 2011 May 18;2011:bar007. doi: 10.1093/database/bar007. Print 2011.
Parkinson's disease (PD) is a common, adult-onset, neuro-degenerative disorder characterized by the degeneration of cardinal motor signs mainly due to the loss of dopaminergic neurons in the substantia nigra. To date, researchers still have limited understanding of the key molecular events that provoke neurodegeneration in this disease. Here, we present ParkDB, the first queryable database dedicated to gene expression in PD. ParkDB contains a complete set of re-analyzed, curated and annotated microarray datasets. This resource enables scientists to identify and compare expression signatures involved in PD and dopaminergic neuron differentiation under different biological conditions and across species. Database URL: http://www2.cancer.ucl.ac.uk/Parkinson_Db2/
帕金森病（PD）是一种常见的成人发病、神经退行性疾病，其特征是主要由于黑质中多巴胺能神经元的丧失而导致主要运动体征的退化。迄今为止，研究人员对引发这种疾病神经退行性变的关键分子事件仍知之甚少。在这里，我们介绍了 ParkDB，这是第一个专门针对 PD 基因表达的可查询数据库。ParkDB 包含一整套经过重新分析、整理和注释的微阵列数据集。该资源使科学家能够识别和比较不同生物条件和物种下与 PD 和多巴胺能神经元分化相关的表达特征。数据库网址：http://www2.cancer.ucl.ac.uk/Parkinson_Db2/
