昂丹司琼（OND）与格拉司琼（GRA）对化疗引起的急性呕吐的控制效果比较
Ondansetron (OND) vs granisetron (GRA) in the control of chemotherapy induced acute emesis.
作者信息
Leonardi V, Iannito E, Meli M, Palmeri S
机构信息
UNIV PALERMO, INST MED CLIN 1, CHAIR MED ONCOL, I-90127 PALERMO, ITALY. UNIV PALERMO, BMT, DIV HAEMATOL, I-90127 PALERMO, ITALY. UNIV PALERMO, MED ONCOL SERV, I-90127 PALERMO, ITALY.
出版信息
Oncol Rep. 1996 Sep;3(5):919-23. doi: 10.3892/or.3.5.919.
We enrolled 118 chemonaive cancer patients (pts) to receive OND i.v. dl or GRA i.v. dl. Seventy of the 118 pts received moderately emetogenic (ME) chemotherapy (140 cycles), while 48 received highly emetogenic (HE) chemotherapy (93 cycles). Therapeutic success was obtained in 89% (OND) vs 94% (GRA) cycles of HE and in 96.8% (OND) vs 95.6% (GRA) cycles of ME. The main toxicities were headache (24%, OND; 23%, GRA); light-headedness (13%, OND; 18%, GRA); constipation (11%, OND; 6%, GRA). In conclusion, we think that OND and GRA are effective and the two drugs are equally active and toxic.
我们招募了118例初治癌症患者接受静脉注射昂丹司琼第1天或格拉司琼第1天治疗。118例患者中，70例接受中度致吐性（ME）化疗（140个周期），而48例接受高度致吐性（HE）化疗（93个周期）。在HE化疗周期中，昂丹司琼组的治疗成功率为89%，格拉司琼组为94%；在ME化疗周期中，昂丹司琼组为96.8%，格拉司琼组为95.6%。主要毒性反应为头痛（昂丹司琼组24%；格拉司琼组23%）；头晕（昂丹司琼组13%；格拉司琼组18%）；便秘（昂丹司琼组11%；格拉司琼组6%）。总之，我们认为昂丹司琼和格拉司琼均有效，两种药物的活性和毒性相当。
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