Francis B M, Huang Y S, Hartig P C, Rosen M B, Kawanishi C Y, Chernoff N
Developmental Toxicology Division, Environmental Protection Agency, Research Triangle Park, NC.
J Appl Toxicol. 1990 Feb;10(1):43-6. doi: 10.1002/jat.2550100108.
Interactions between exposure to xenobiotics and disease can occur during pregnancy. Few data are available on the consequences of such interactions on developmental parameters. In this study, we investigated potential interactions between murine cytomegalovirus (MCMV), which induces embryolethality, and sodium salicylate, a known teratogen. MCMV administered on Day 12 was embryotoxic over a broad range of doses from 2 x 10(3) to 2 x 10(6) plaque-forming units, and also decreased postnatal weight gain. MCMV administration on Day 8 of gestation caused significant prenatal mortality regardless of salicylate exposure. Salicylate did not cause fetal mortality or malformations at either 500 or 750 mg kg-1 day-1 on Days 9 and 10 of gestation. No evidence of synergistic effects of MCMV and salicylate on embryo/fetal development was seen.
孕期可能会发生接触外源性物质与疾病之间的相互作用。关于此类相互作用对发育参数的影响，目前可用的数据很少。在本研究中，我们调查了诱导胚胎致死的小鼠巨细胞病毒（MCMV）与已知致畸剂水杨酸钠之间的潜在相互作用。在第12天给予MCMV，在2×10³至2×10⁶ 空斑形成单位的广泛剂量范围内具有胚胎毒性，并且还降低了出生后的体重增加。在妊娠第8天给予MCMV，无论是否接触水杨酸盐，都会导致显著的产前死亡率。在妊娠第9天和第10天，水杨酸盐在500或750 mg kg⁻¹ day⁻¹剂量下均未导致胎儿死亡或畸形。未发现MCMV和水杨酸盐对胚胎/胎儿发育有协同作用的证据。
