Department of Dermatology, Faculty of Health Sciences, University of Copenhagen, Roskilde Hospital, Koegevej 7-13, DK-4000 Roskilde, Denmark.
J Biophotonics. 2011 Aug;4(7-8):544-51. doi: 10.1002/jbio.201100006. Epub 2011 May 19.
Optical coherence tomography (OCT) has the potential to diagnose and measure the depth of nonmelanoma skin cancer (NMSC) in skin, but some lesions appear blurred in OCT images. The aim of this study is to identify histological characteristics of basal cell carcinomas (BCC) that correlate with good quality OCT images of the same lesions. A total of 34 patients with BCC were OCT scanned. The influence of histology parameters (e.g. inflammation, sun damage of skin, carcinoma cell size) on OCT image quality was studied by comparing 15 BCC lesions easily identified compared to 19 BCC lesions that produced only blurred in OCT images. Inflammation was more pronounced in blurred OCT images, whereas solar elastosis dominated in easily identified lesions. Hyperkeratosis did not impair imaging significantly. OCT image quality of BCC may depend on specific histology parameters.
光学相干断层扫描（OCT）有潜力用于诊断和测量皮肤中的非黑色素瘤皮肤癌（NMSC），但一些病变在 OCT 图像中显示模糊。本研究旨在确定与同一病变的高质量 OCT 图像相关的基底细胞癌（BCC）的组织学特征。共有 34 名 BCC 患者接受了 OCT 扫描。通过比较 15 个易于识别的 BCC 病变与 19 个仅在 OCT 图像中显示模糊的 BCC 病变，研究了组织学参数（如炎症、皮肤日光损伤、癌细胞大小）对 OCT 图像质量的影响。在模糊的 OCT 图像中炎症更为明显，而在易于识别的病变中，太阳弹性组织变性占主导地位。角化过度对成像的影响不显著。BCC 的 OCT 图像质量可能取决于特定的组织学参数。
