成功用干扰素α治疗慢性假性晶状体黄斑水肿（Irvine-Gass 综合征）：三例报告。
Successful treatment of chronic pseudophakic macular edema (Irvine-Gass syndrome) with interferon alpha: a report of three cases.
机构信息
Centre for Ophthalmology, University of Tübingen, Tübingen, Germany.
出版信息
Ocul Immunol Inflamm. 2011 Jun;19(3):216-8. doi: 10.3109/09273948.2011.562341.
PURPOSE
To describe treatment of chronic Irvine-Gass syndrome (CME) with interferon (IFN) alpha.
METHODS
Interventional retrospective case series. IFN alpha-2a was administered at a dose of 3 million IU/day subcutaneously for 4 weeks, and was tapered thereafter. Treatment efficacy was assessed by best-corrected visual acuity (BCVA) and by optical coherence tomography (OCT).
RESULTS
Three patients (4 eyes) with chronic Irvine-Gass syndrome were treated. Ineffective pretreatment included local and systemic corticosteroids. Within 4 weeks, IFN alpha led to resolution of CME in all eyes. BCVA improved in 3 eyes and remained unchanged in 1 eye. During follow-up of 3-11 months no relapse of CME occurred. No systemic or local side effects were noted.
CONCLUSIONS
IFN alpha has been demonstrated to be a successful and well-tolerated treatment option for resistant chronic pseudophakic CME. Further studies are necessary to evaluate the role of IFN alpha in Irvine-Gass syndrome.
目的
描述干扰素（IFN）α治疗慢性 Irvine-Gass 综合征（CME）。
方法
介入性回顾性病例系列。IFN α-2a 以 300 万 IU/天的剂量皮下给药 4 周，然后逐渐减量。通过最佳矫正视力（BCVA）和光学相干断层扫描（OCT）评估治疗效果。
结果
3 例（4 只眼）慢性 Irvine-Gass 综合征患者接受了治疗。无效的预处理包括局部和全身皮质类固醇。IFN α 在 4 周内使所有眼睛的 CME 得到缓解。3 只眼的 BCVA 改善，1 只眼不变。在 3-11 个月的随访中，CME 无复发。未观察到全身或局部副作用。
结论
IFN α已被证明是一种成功且耐受良好的治疗抵抗性慢性假性晶状体 CME 的选择。需要进一步研究来评估 IFN α 在 Irvine-Gass 综合征中的作用。
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