Department of Molecular Pathology, Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Tokyo, Japan.
Cancer Sci. 2011 Jun;102(6):1242-4. doi: 10.1111/j.1349-7006.2010.01806.x.
The Fujihara International Seminar series is supported by the Fujihara Foundation for Science, for the purpose of organizing seminars for basic and applied science, including medical science, physics, chemistry, engineering, mathematics, geology, and biology. The 59th Fujihara International Seminar was held on July 14-17, 2010 at Tomakomai, Hokkaido, Japan, focusing on molecular mechanisms of transforming growth factor (TGF)-β signaling and disease. Recent findings on mechanisms of TGF-β signaling, the roles of TGF-β signaling in carcinogenesis and progression of tumors, and possible strategies of TGF-β-based treatment of cancer were discussed at the seminar. In particular, novel mechanisms of regulation of Smad signaling, the differential roles of Smad proteins in carcinogenesis, function of Smads in regulation of microRNA biogenesis, and treatment of cancer stem cells by targeting the TGF-β signaling pathways were discussed.
藤原国际研讨会系列由藤原科学基金会支持，旨在组织基础科学和应用科学研讨会，包括医学、物理学、化学、工程学、数学、地质学和生物学。第 59 届藤原国际研讨会于 2010 年 7 月 14 日至 17 日在日本北海道的苫小牧市举行，会议重点是转化生长因子 (TGF)-β信号转导和疾病的分子机制。在研讨会上讨论了 TGF-β信号转导的最新发现、TGF-β信号转导在肿瘤发生和进展中的作用以及基于 TGF-β的癌症治疗的可能策略。特别是，探讨了调节 Smad 信号转导的新机制、Smad 蛋白在肿瘤发生中的不同作用、Smads 在调节 microRNA 生物发生中的功能以及通过靶向 TGF-β信号通路治疗癌症干细胞的新机制。
