Kaseda Ryohei, Hosojima Michihiro, Sato Hiroyoshi, Saito Akihiko
Division of Clinical Nephrology and Rheumatology, Niigata University Graduate School of Medical and Dental Sciences, Asahimachi-dori, Chuo-ku, Niigata, Japan.
Ther Apher Dial. 2011 Jun;15 Suppl 1:14-7. doi: 10.1111/j.1744-9987.2011.00920.x.
Vitamin D deficiency is associated with various medical conditions including musculoskeletal disorders, infection, metabolic diseases, and cardiovascular disease. Megalin and cubilin, endocytic receptors in proximal tubule cells, are involved in the reabsorption of vitamin D binding protein from glomerular filtrates and the subsequent intracellular conversion of 25-hydroxyvitamin D(3) to biologically active 1α,25-dihydroxyvitamin D(3). Dysfunction of these receptors, which is commonly found in patients with diabetic nephropathy, even at early stages, may explain why vitamin D deficiency is often complicated in these patients. Therapeutic strategies to protect the functions of these receptors from injury could be used to prevent vitamin D deficiency and its related disorders.
维生素D缺乏与多种医学状况相关，包括肌肉骨骼疾病、感染、代谢性疾病和心血管疾病。巨蛋白和 cubilin 是近端小管细胞中的内吞受体，参与从肾小球滤液中重吸收维生素D结合蛋白以及随后将25-羟基维生素D(3)细胞内转化为具有生物活性的1α,25-二羟基维生素D(3)。这些受体功能障碍在糖尿病肾病患者中很常见，甚至在早期阶段也是如此，这可能解释了为什么这些患者常并发维生素D缺乏。保护这些受体功能免受损伤的治疗策略可用于预防维生素D缺乏及其相关疾病。
