正常和胆汁淤积胎盘中核受体 FXR、PXR 和 CAR 的特征。
Characterisation of the nuclear receptors FXR, PXR and CAR in normal and cholestatic placenta.
机构信息
Institute of Reproductive and Developmental Biology, Imperial College London, Du Cane Road, UK.
出版信息
Placenta. 2011 Jul;32(7):535-7. doi: 10.1016/j.placenta.2011.04.014. Epub 2011 May 18.
Bile acids are the toxic end products of hepatic cholesterol metabolism. They are synthesised from early in gestation and excreted via the placenta. The mechanism for transplacental excretion of bile acids is not known. The gene and protein expression of the nuclear receptors responsible for hepatic bile acid metabolism and transport was studied in eight normal and fourteen cholestatic placentas, and in an ex vivo model. The expression of the nuclear receptor FXR and several of it's target genes and of PXR and CAR was found to be very low in both normal and cholestatic placenta.
胆酸是肝脏胆固醇代谢的有毒终产物。它们从妊娠早期开始合成，并通过胎盘排泄。胆酸经胎盘排泄的机制尚不清楚。本研究在 8 例正常胎盘和 14 例胆汁淤积性胎盘及体外模型中，研究了负责肝脏胆酸代谢和转运的核受体的基因和蛋白表达。结果发现，正常和胆汁淤积性胎盘的核受体 FXR 及其几个靶基因和 PXR、CAR 的表达均非常低。
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