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治疗 5413 例高血压患者:一项横断面研究。

Treatment of 5413 hypertensive patients: a cross-sectional study.

机构信息

Research Unit of General Practice, Institute of Public Health, University of Southern Denmark, Odense.

出版信息

Fam Pract. 2011 Dec;28(6):599-607. doi: 10.1093/fampra/cmr027. Epub 2011 May 19.

Abstract

BACKGROUND

Most hypertensive patients are managed in primary care in Denmark, but previous studies have shown that only 21-43% of hypertensive patients achieve optimal blood pressure (BP) control. Antihypertensive drug treatment, risk factors and cardiovascular disease (CVD) are some of the important factors to consider when optimizing the individual treatment strategy in hypertensive patients.

OBJECTIVE

To examine treatment of BP according to Danish guidelines (BP < 140/90 mmHg generally and <130/80 mmHg for diabetics) in a population from general practice in relation to risk factors, CVD and diagnosis of diabetes.

METHODS

A cross-sectional study comprising 184 practices and 5413 hypertensive patients was carried out in Denmark. The general practitioners filled in information on each patient's risk factors, CVD and antihypertensive drug treatment. Patients filled in a questionnaire on risk factors. The outcome measures were optimal BP control according to Danish guidelines and antihypertensive drug treatment.

RESULTS

Mean patient age was 65.9 years [95% confidence interval (CI): 65.6-66.1]. Optimal BP control was achieved in 29.1% (95% CI: 27.9-30.3) of the study population. Among 842 diabetics with or without CVD, optimal BP control was achieved in 10.9% (95% CI: 8.8-10.3), while 38.7% (35.5-41.9) of patients with CVD achieved optimal BP control. The majority of all patients were treated with 1 (32.5%, 95% CI: 32.5 (31.3-33.8)) or two antihypertensive drugs (39.0%, 95% CI: 38.2-40.8). In hypertensive diabetics, 17.7% were not treated with an angiotensin-converting enzyme inhibitor or angiotensin-receptor blocker.

CONCLUSION

In general practice, the proportion of hypertensive patients achieving optimal BP control is inadequate. The majority of hypertensive patients are treated with only one or two antihypertensive drugs.

摘要

背景

在丹麦,大多数高血压患者在初级保健中得到管理,但先前的研究表明,只有 21-43%的高血压患者实现了最佳血压(BP)控制。降压药物治疗、危险因素和心血管疾病(CVD)是优化高血压患者个体治疗策略时需要考虑的一些重要因素。

目的

检查丹麦指南(一般情况下 BP<140/90mmHg,糖尿病患者<130/80mmHg)指导下的降压治疗在一般实践中的高血压患者中与危险因素、CVD 和糖尿病诊断的关系。

方法

在丹麦进行了一项横断面研究,涉及 184 个实践和 5413 名高血压患者。全科医生填写了每位患者的危险因素、CVD 和降压药物治疗信息。患者填写了一份关于危险因素的问卷。主要结局指标是根据丹麦指南实现最佳 BP 控制和降压药物治疗。

结果

患者平均年龄为 65.9 岁[95%置信区间(CI):65.6-66.1]。研究人群中,29.1%(95%CI:27.9-30.3)达到了最佳 BP 控制。在有或没有 CVD 的 842 名糖尿病患者中,最佳 BP 控制达到了 10.9%(95%CI:8.8-10.3),而 38.7%(35.5-41.9)的 CVD 患者达到了最佳 BP 控制。大多数患者服用一种(32.5%,95%CI:32.5(31.3-33.8))或两种降压药物(39.0%,95%CI:38.2-40.8)。在高血压糖尿病患者中,17.7%未接受血管紧张素转换酶抑制剂或血管紧张素受体阻滞剂治疗。

结论

在一般实践中,达到最佳 BP 控制的高血压患者比例不足。大多数高血压患者仅用一种或两种降压药物治疗。

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