Department of Neurosurgery, College of Medicine, Ewha Womans University, Seoul, Korea.
AJNR Am J Neuroradiol. 2011 Jun-Jul;32(6):1087-90. doi: 10.3174/ajnr.A2458. Epub 2011 May 19.
The optimal management of patients with unruptured intracranial aneurysms remains controversial in elderly populations. The aim of this study was to evaluate technical results and clinical outcomes in a single center of consecutive elderly patients with unruptured intracranial aneurysms treated with endovascular embolization.
Between May 2003 and February 2010, 96 patients older than 70 years (men, 16 patients; women, 80 patients; mean age, 73 years) with 122 saccular unruptured intracranial aneurysms were treated in our hospital with an endovascular approach. The endovascular procedures and technique, angiographic follow-up, and complications were evaluated.
Successful embolizations without complications were completed in 95.9%. Five patients had procedure-related events, including thromboembolism in 1 patient, aneurysm perforation during the procedure in 1, and 3 postoperative transient minor symptoms (headache, otalgia, and trigeminal pain) in 3. The degree of occlusion of the treated aneurysm was complete in 46.7%; there was a small neck remnant in 40.9% and residual filling in 12.2%. Imaging (MR angiography) follow-up was performed in 68.7% of the patients. The mean follow-up duration was 19.4 months (range, 5-57 months). Fifty-five patients (93.9%) showed no interval change of the residual neck. Four (6%) demonstrated recanalizations, all of which were successfully recoiled.
Endovascular treatment of unruptured intracranial aneurysms in patients older than 70 years of age appears to be safe. Favorable outcomes with low morbidities may replace surgery or conservative treatment as an active management alternative.
老年人颅内未破裂动脉瘤的最佳治疗方案仍存在争议。本研究旨在评估单一中心连续收治的高龄颅内未破裂动脉瘤患者行血管内栓塞治疗的技术效果和临床转归。
2003 年 5 月至 2010 年 2 月,我院共收治 96 例年龄大于 70 岁(男 16 例,女 80 例;平均年龄 73 岁)的颅内未破裂囊状动脉瘤患者,共 122 个动脉瘤,均采用血管内治疗。评估血管内治疗的过程和技术、血管造影随访和并发症。
95.9%的患者成功完成了无并发症的栓塞治疗。5 例患者发生了与手术相关的事件,包括 1 例血栓栓塞、1 例术中动脉瘤破裂和 3 例术后短暂的轻微症状(头痛、耳痛和三叉神经痛)。治疗后动脉瘤的闭塞程度完全闭塞 46.7%,小颈残留 40.9%,残余充盈 12.2%。对 68.7%的患者进行了影像学(磁共振血管造影)随访。平均随访时间为 19.4 个月(5~57 个月)。55 例(93.9%)患者的残余颈部未见间隔性变化。4 例(6%)出现再通,均成功再通。
对于 70 岁以上的颅内未破裂动脉瘤患者,血管内治疗是安全的。良好的预后和较低的发病率可能取代手术或保守治疗,成为一种积极的治疗选择。