Department of Health Sciences, Northeastern University, Boston, MA 02115, USA.
Psychosom Med. 2011 Jun;73(5):385-92. doi: 10.1097/PSY.0b013e31821a1ab4. Epub 2011 May 19.
To examine the associations between variants of genes involved in the uptake, retention, and metabolism of folate and depressive symptoms and to analyze whether such associations are direct or through mediation by folate or homocysteine.
We performed a cross-sectional analysis of data from 976 Puerto Rican adults, aged 45 to 75 years, residing in the greater Boston area, Massachusetts. Twelve single nucleotide polymorphisms (SNPs) in genes involved in folate uptake, retention, and metabolism were investigated. These include FOLH1 (folate hydrolase), FPGS (folate polyglutamate synthase), GGH (γ-glutamyl hydrolase), MTHFR (methylenetetrahydrofolate reductase), MTR (methionine synthase), PCFT (proton-coupled folate transporter), and RFC1 (reduced folate carrier 1). The Center for Epidemiologic Studies Depression Scale (CES-D) was used to measure depressive symptoms.
The FOLH1 rs61886492 C>T (or 1561C>T) polymorphism was significantly associated with lower CES-D score (p = .0025) after adjusting for age, sex, population admixture, smoking, and educational attainment. Individuals with the TT and TC genotypes were 49% less likely (odds ratio = 0.51, 95% confidence interval = 0.29-0.89) to report mild depressive symptoms (CES-D score ≥16 and ≤26) and 64% less likely (odds ratio = 0.36, 95% confidence interval = 0.18-0.69) to report moderate to severe depressive symptoms (CES-D score >26), compared with those with the CC genotype. No significant mediation effects by plasma folate or homocysteine on the associations between this single nucleotide polymorphism and CES-D score were observed.
The FOLH1 1561C>T polymorphism may be associated with the risk of depressive symptoms.
研究参与叶酸摄取、保留和代谢的基因变异与抑郁症状之间的关联，并分析这些关联是否是直接的，还是通过叶酸或同型半胱氨酸的中介作用。
我们对居住在马萨诸塞州波士顿大都市区的 976 名年龄在 45 至 75 岁的波多黎各成年人进行了横断面数据分析。研究了参与叶酸摄取、保留和代谢的 12 个单核苷酸多态性（SNP）。这些基因包括 FOLH1（叶酸水解酶）、FPGS（叶酸多谷氨酸合酶）、GGH（γ-谷氨酰水解酶）、MTHFR（亚甲基四氢叶酸还原酶）、MTR（蛋氨酸合酶）、PCFT（质子偶联叶酸转运体）和 RFC1（还原叶酸载体 1）。使用流行病学研究抑郁量表（CES-D）来衡量抑郁症状。
在调整年龄、性别、人群混合、吸烟和受教育程度后，FOLH1 rs61886492 C>T（或 1561C>T）多态性与 CES-D 评分较低显著相关（p=0.0025）。与 CC 基因型相比，TT 和 TC 基因型的个体报告轻度抑郁症状（CES-D 评分≥16 且≤26）的可能性降低 49%（比值比=0.51，95%置信区间=0.29-0.89），报告中重度抑郁症状（CES-D 评分>26）的可能性降低 64%（比值比=0.36，95%置信区间=0.18-0.69）。未观察到该单核苷酸多态性与 CES-D 评分之间的关联通过血浆叶酸或同型半胱氨酸产生显著的中介作用。
FOLH1 1561C>T 多态性可能与抑郁症状的风险相关。
