Cardiovascular Division, King's College London British Heart Foundation Centre, London SE5 9PJ, UK.
Basic Res Cardiol. 2011 Sep;106(5):735-47. doi: 10.1007/s00395-011-0190-z. Epub 2011 May 20.
NADPH oxidase family enzymes (or NOXs) are the major sources of reactive oxygen species (ROS) that are implicated in the pathophysiology of many cardiovascular diseases. These enzymes appear to be especially important in the modulation of redox-sensitive signalling pathways that underlie key cellular functions such as growth, differentiation, migration and proliferation. Seven distinct members of the family have been identified of which four (namely NOX1, 2, 4 and 5) may have cardiovascular functions. In this article, we review our current understanding of the roles of NOX enzymes in several common cardiovascular disease states, with a focus on data from genetic studies and clinical data where available.
NADPH 氧化酶家族酶（或 NOXs）是活性氧（ROS）的主要来源，它们与许多心血管疾病的病理生理学有关。这些酶似乎在调节氧化还原敏感的信号通路中特别重要，这些信号通路是细胞的关键功能（如生长、分化、迁移和增殖）的基础。该家族已确定有 7 个不同的成员，其中 4 个（即 NOX1、2、4 和 5）可能具有心血管功能。在本文中，我们回顾了我们目前对 NOX 酶在几种常见心血管疾病状态中的作用的理解，重点介绍了遗传研究和临床数据中的数据。
