Potapova A A, Koval'chuk L V
Zh Mikrobiol Epidemiol Immunobiol. 2011 Mar-Apr(2):48-53.
Comparison of alpha-fetoprotein (AFP) levels in blood sera samples of women in the early stages of pregnancy with positive or indeterminate results of anti-HCV.
Blood sera samples of women in the first trimester of pregnancy were analyzed by using microplate test systems for enzyme immunoassay (EIA) with complex and separate detection of antibodies against hepatitis C virus (HCV) antigens.
AFP levels were higher in women in the first trimester of pregnancy with anti-HCV than in women without anti-HCV. AFP levels in blood sera samples of pregnant women with indeterminate results of anti-HCV analysis were higher than in blood sera samples of pregnant women without anti-HCV. No differences in serum AFP levels were observed between anti-HCV positive samples and samples with indeterminate results of analysis.
Increased AFP level in the first trimester of pregnancy was observed not only in women with HCV infection, but also in women with indeterminate results of anti-HCV analysis. The data suggest that these groups may have epidemiological similarity.
比较抗丙型肝炎病毒（HCV）结果为阳性或不确定的妊娠早期女性血清样本中甲胎蛋白（AFP）水平。
采用酶免疫分析（EIA）微孔板检测系统，对妊娠早期女性血清样本进行分析，以综合及分别检测抗丙型肝炎病毒（HCV）抗原的抗体。
抗HCV的妊娠早期女性血清中的AFP水平高于无抗HCV的女性。抗HCV分析结果不确定的孕妇血清样本中的AFP水平高于无抗HCV的孕妇血清样本。抗HCV阳性样本与分析结果不确定的样本之间血清AFP水平未观察到差异。
不仅在HCV感染女性中，而且在抗HCV分析结果不确定的女性中，均观察到妊娠早期AFP水平升高。数据表明这些组可能具有流行病学相似性。
