Kozyreva T V, Kozaruk V P, Tkachenko E Ia, Khramova G M
Ross Fiziol Zh Im I M Sechenova. 2011 Feb;97(2):218-26.
In rats, the effect of activation of the cold- and menthol-sensitive TRPM8 ion channel on different thermoregulatory parameters: total oxygen consumption, carbon dioxide release, respiration coefficient, constriction response of skin blood vessels, muscle activity, was studied. Activation of TRPM8 with menthol even in thermoneutral conditions produces an increase in oxygen consumption and a decrease in respiratory coefficient, which may suggest enhanced non-shivering thermogenesis and lipolysis. Rapid cooling against the background of TRPM8 activation is characterized by a decrease in the temperature thresholds of all thermoregulatory responses without associated changes in sequences of their initiation as well as in enhancement of metabolic component of emergency thermogenesis which leads to improved maintenance of core temperature in conditions when external cold acts on the organism. The obtained data on the effect of TRPM8 activation on metabolic parameters in thermoneutral conditions and under cooling suggest acontinuous involvement of this receptor in regulation of total metabolism and, possibly, in determination of the type of organism's metabolism as well as in determination of organism's response to external cooling.
在大鼠中，研究了激活冷敏和薄荷醇敏感的TRPM8离子通道对不同体温调节参数的影响：总耗氧量、二氧化碳释放量、呼吸系数、皮肤血管收缩反应、肌肉活动。即使在热中性条件下，用薄荷醇激活TRPM8也会导致耗氧量增加和呼吸系数降低，这可能表明非颤抖性产热和脂肪分解增强。在TRPM8激活的背景下快速冷却的特征是所有体温调节反应的温度阈值降低，其启动顺序没有相关变化，以及紧急产热的代谢成分增强，这导致在外部寒冷作用于机体的情况下更好地维持核心体温。关于TRPM8激活对热中性条件下和冷却时代谢参数影响的所得数据表明，该受体持续参与总代谢的调节，可能还参与机体代谢类型的确定以及机体对外部冷却的反应的确定。
