Cdk5：神经元发育、死亡和 DNA 损伤反应的介质。
Cdk5: mediator of neuronal development, death and the response to DNA damage.
机构信息
Department of Pharmacology, Emory University School of Medicine, Whitehead Bldg., Rm505L 615 Michael St., Atlanta, GA 30322, USA.
出版信息
Mech Ageing Dev. 2011 Aug;132(8-9):389-94. doi: 10.1016/j.mad.2011.04.011. Epub 2011 May 11.
Abstract
In the central nervous system, cyclin-dependent kinase 5 (Cdk5), an unusual member of the Cdk family, is implicated in the regulation of various physiological processes ranging from neuronal survival, migration and differentiation, to synaptogenesis, synaptic plasticity and neurotransmission. Dysregulation of this kinase has been demonstrated to play a critical role in the pathogenic process of neurodegenerative disorders. DNA damage is emerging as an important pathological component in various neurodegenerative conditions. In this review, we discuss the recent progress regarding the regulation and roles of Cdk5 under physiological conditions, and its dysregulation under pathological conditions, especially in neuronal death mediated by DNA damage.
摘要
在中枢神经系统中，细胞周期蛋白依赖性激酶 5（Cdk5）是 CDK 家族的一个特殊成员，它参与调节各种生理过程，包括神经元存活、迁移和分化，以及突触发生、突触可塑性和神经传递。该激酶的失调已被证明在神经退行性疾病的发病过程中起着关键作用。DNA 损伤正在成为各种神经退行性疾病的一个重要病理组成部分。在这篇综述中，我们讨论了 Cdk5 在生理条件下的调节和作用及其在病理条件下的失调的最新进展，特别是在 DNA 损伤介导的神经元死亡中的作用。
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