5-羟色胺介导的促肾上腺皮质激素释放因子 mRNA 表达和摄食行为改变局限于下丘脑室旁核。
Serotonin mediated changes in corticotropin releasing factor mRNA expression and feeding behavior isolated to the hypothalamic paraventricular nuclei.
机构信息
Department of Biomedical Sciences, Marquette University, Schroeder Complex 446, P.O. Box 1881, Milwaukee, WI 53201, United States.
出版信息
Neurosci Lett. 2011 Jul 12;498(3):213-7. doi: 10.1016/j.neulet.2011.05.011. Epub 2011 May 11.
Abstract
Fenfluramine reduces hunger and promotes body weight loss by increasing central serotonin (5-HT) signaling. More recently, neuropeptides have been linked to the regulation of feeding behavior, metabolism and body weight. To examine possible interactions between 5-HT and neuropeptides in appetite control, fenfluramine (200 nmol/0.5 μl/side) was administered directly into the hypothalamic paraventricular nuclei (PVN) of male rats. Bilateral fenfluramine produced significant hypophagia and increased expression of PVN corticotropin releasing factor (CRF) mRNA and neuropeptide Y (NPY) mRNA in the arcuate nucleus within the first hour after drug administration. Fenfluramine's effects on feeding behavior and mRNA expression were blocked by PVN injections of a 5-HT(1-2) receptor antagonist, metergoline (15 nmol/0.5 μl/side). These data suggest that 5-HT neurons targeting hypothalamic paraventricular CRF neurons may participate in an appetite control circuit for reducing food intake.
摘要
芬氟拉明通过增加中枢 5-羟色胺（5-HT）信号来减少饥饿感并促进体重减轻。最近，神经肽与进食行为、代谢和体重的调节有关。为了研究 5-HT 和神经肽在食欲控制中的可能相互作用，将芬氟拉明（200nmol/0.5μl/侧）直接注射到雄性大鼠的下丘脑室旁核（PVN）中。双侧芬氟拉明给药后 1 小时内，可显著减少食欲，并增加弓状核中促肾上腺皮质释放因子（CRF）mRNA 和神经肽 Y（NPY）mRNA 的表达。PVN 注射 5-HT（1-2）受体拮抗剂麦角乙脲（15nmol/0.5μl/侧）可阻断芬氟拉明对摄食行为和 mRNA 表达的影响。这些数据表明，靶向下丘脑室旁核 CRF 神经元的 5-HT 神经元可能参与了减少食物摄入的食欲控制回路。
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