Berger H, Bergholz M, Heil M
Abteilung Dermato-Histologie, Universitäts-Hautklinik Göttingen.
Z Hautkr. 1990 Mar;65(3):277-81.
With the help of immunohistochemical techniques and new antibodies developed in the last few years, we were able to identify 2 cases of nodular tumors of the skin as highly malignant Ki-1 lymphomas. The clinical course was characterized by the development of multiple skin tumors without any evidence of systemic involvement. After the excision of several skin tumors; we performed chemotherapy with the MACOP-B regimen. In one of our patients, however, this treatment could not prevent the occurrence of further tumors. Possibly, the cutaneous anaplastic Ki-1 lymphomas presented here are closely related to or even identical with mycosis fungoides d'emblée.
借助免疫组化技术以及近年来研发的新型抗体,我们得以将2例皮肤结节状肿瘤确诊为高度恶性的Ki-1淋巴瘤。临床病程的特点是出现多发性皮肤肿瘤,且无任何全身受累的迹象。在切除数处皮肤肿瘤后,我们采用MACOP-B方案进行化疗。然而,在我们的一名患者中,这种治疗未能阻止进一步肿瘤的出现。此处呈现的皮肤间变性Ki-1淋巴瘤可能与原发性蕈样肉芽肿密切相关甚至完全相同。