[Clinical and neurohumoral indicators in women-alcoholics of reproductive and climacteric age].

As many as 94 women of reproductive and climacteric age were subjected to clinical and laboratory studies. Women of reproductive age demonstrated abnormalities of menstrual function of the type of ovulatory and anovulatory hemorrhages. The group over 40 years manifested an early onset of menopause. Alcoholism standing was from 2 to 15 years. Study of the neurohumoral characteristics in women suffering from alcoholism during abstinence revealed a considerable lowering of serotonin content in the blood as compared with normals. The content of acetylcholine, the activity of genuine and false blood cholinesterase were increased in women suffering from alcoholism, pointing to excitation in the cholinergic system. During abstinence, women of reproductive and climacteric age suffering from alcoholism demonstrated discrepancy in the activity of the neuromediator systems.