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全肺切除术后再次肺切除的体外二氧化碳去除。

Extracorporeal carbon dioxyde removal for additional pulmonary resection after pneumonectomy.

机构信息

Unit of Anesthesia and Resuscitation, Local Health Unit Bari, San Paolo Hospital, Bari, Italy.

出版信息

Minerva Anestesiol. 2012 Mar;78(3):381-4.

PMID:21602748
Abstract

Additional pulmonary surgery in a previously pneumonectomized patient requires apnea during surgical manipulation of the surviving lung. We report on a novel approach to manage the intraoperative apnea period, combining apneic oxygenation and minimally invasive, low flow extracorporeal CO2 removal. A 69-year-old man previously submitted to left pneumonectomy was scheduled for wedge resection of a single right upper lobe lesion. During the intraoperative apnea period, oxygenation was maintained through apneic oxygenation with continuous positive airway pressure (CPAP) of 5 cmH2O and inspiratory oxygen fraction (FiO2) of 1 and respiratory acidosis was prevented through extracorporeal CO2 removal, performed with the Decap® system (Hemodec, Salerno, Italy), a veno¬venous pump-driven extracorporeal circuit including a neonatal membrane lung. The extracorporeal circuit was connected to the right femoral vein, accessed via a 14 Fr double lumen catheter. The blood flow through the circuit was 350 mL/min and the sweep flow of oxygen through the membrane lung was 8 L/min. The intraoperative apnea period lasted 13 minutes. Our approach allowed maintaining normocapnia (PaCO2 38,5 and 40 mmHg before and at the end of the apnea period, respectively), preserving oxygenation (P/F ratio 378, 191, 198 and 200 after 3, 6, 9 and 12 min of apnea, respectively). Our report suggests that the minimally invasive CO2 removal associated with apneic oxygenation is an useful technique for managing anesthesiological situations requiring moderate apnea periods.

摘要

在曾行过肺切除术的患者中进行附加的肺外科手术需要在手术操作存活肺时进行呼吸暂停。我们报告了一种管理术中呼吸暂停期的新方法,结合了无通气氧合和微创、低流量体外 CO2 去除。一位 69 岁的男性曾行左侧全肺切除术,因单个右上肺叶病变行楔形切除术。在术中呼吸暂停期间,通过 5 cmH2O 的持续气道正压通气(CPAP)和 1 的吸气氧分数(FiO2)进行无通气氧合来维持氧合,通过体外 CO2 去除来预防呼吸性酸中毒,体外 CO2 去除通过 Decap®系统(Hemodec,Salerno,意大利)进行,该系统是一种包括新生儿膜肺的静脉-静脉泵驱动体外回路。体外回路连接到右侧股静脉,通过 14Fr 双腔导管进入。回路中的血流为 350 mL/min,膜肺中的氧气吹扫流量为 8 L/min。术中呼吸暂停期持续 13 分钟。我们的方法允许维持正常碳酸血症(呼吸暂停前和结束时的 PaCO2 分别为 38.5 和 40mmHg),保持氧合(呼吸暂停后 3、6、9 和 12 分钟时的 P/F 比值分别为 378、191、198 和 200)。我们的报告表明,与无通气氧合相关的微创 CO2 去除是管理需要中度呼吸暂停期的麻醉学情况的有用技术。

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Extracorporeal carbon dioxide removal (ECCOR) in respiratory deficiency and current investigations on its improvement: a review.呼吸功能不全时的体外二氧化碳清除(ECCOR)及其改善的当前研究:综述
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Carbon dioxide dialysis in a swine model utilizing systemic and regional anticoagulation.
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