Kapoor G, Bagai U, Banyal H S
Laboratory of Parasitology and Immunology, Department of Biosciences, Himachal Pradesh University,Shimla 171005, India.
Trop Biomed. 2011 Apr;28(1):119-24.
Intracellular parasites manipulate host cell apoptosis in different ways either to increase their life span within infected cells or to spread infection. The present data provided information on the cellular changes taking place in spleen and peripheral blood during Plasmodium berghei-infection and indicated apoptosis mediated host immune response during infection. Our results suggested a significant change in cellular composition and absolute number of white blood cells in spleen and peripheral blood of P. berghei-infected Balb/c mice. Plasmodium berghei-infection was associated with marked increase in percentage of apoptotic mononuclear cells compared to polymorphonuclear white blood cells.
细胞内寄生虫通过不同方式操纵宿主细胞凋亡，以延长其在感染细胞内的存活时间或传播感染。目前的数据提供了关于伯氏疟原虫感染期间脾脏和外周血中发生的细胞变化的信息，并表明感染期间凋亡介导了宿主免疫反应。我们的结果表明，感染伯氏疟原虫的Balb/c小鼠的脾脏和外周血中白细胞的细胞组成和绝对数量发生了显著变化。与多形核白细胞相比，伯氏疟原虫感染与凋亡单核细胞百分比的显著增加有关。
