Role of the tumor-associated trypsin inhibitor SPINK1 in cancer development.
作者信息
Stenman Ulf-Håkan
机构信息
Deparment of Clinical Chmistry, Helsinki University, Finland.
出版信息
Asian J Androl. 2011 Jul;13(4):628-9. doi: 10.1038/aja.2011.45. Epub 2011 May 23.
Abstract
摘要
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Role of the tumor-associated trypsin inhibitor SPINK1 in cancer development.肿瘤相关胰蛋白酶抑制剂SPINK1在癌症发展中的作用。
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The impact of physiological stress conditions on protein structure and trypsin inhibition of serine protease inhibitor Kazal type 1 (SPINK1) and its N34S variant.生理应激条件对丝氨酸蛋白酶抑制剂 Kazal 型 1（SPINK1）及其 N34S 变体的蛋白质结构和胰蛋白酶抑制作用的影响。
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Defective binding of SPINK1 variants is an uncommon mechanism for impaired trypsin inhibition in chronic pancreatitis.SPINK1 变异体的结合缺陷是慢性胰腺炎中胰蛋白酶抑制作用受损的一种不常见机制。
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Absence of PRSS1 mutations and association of SPINK1 trypsin inhibitor mutations in hereditary and non-hereditary chronic pancreatitis.遗传性和非遗传性慢性胰腺炎中PRSS1突变的缺失及SPINK1胰蛋白酶抑制剂突变的相关性
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Roles of serine protease inhibitor Kazal type 1 (SPINK1) in pancreatic diseases.丝氨酸蛋白酶抑制剂 Kazal 型 1（SPINK1）在胰腺疾病中的作用。
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Interleukin-6 increases expression of serine protease inhibitor Kazal type 1 through STAT3 in colorectal adenocarcinoma.白细胞介素-6通过信号转导和转录激活因子3增加结直肠癌中Kazal型丝氨酸蛋白酶抑制剂1的表达。
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MAPK inhibitors induce serine peptidase inhibitor Kazal type 1 (SPINK1) secretion in BRAF V600E-mutant colorectal adenocarcinoma.MAPK 抑制剂诱导 BRAF V600E 突变型结直肠腺癌中丝氨酸蛋白酶抑制剂 Kazal 型 1（SPINK1）分泌。
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Mutations in serine protease inhibitor Kazal type 1 are strongly associated with chronic pancreatitis.丝氨酸蛋白酶抑制剂Kazal型1的突变与慢性胰腺炎密切相关。
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SPINK1 is a prognosis predicting factor of non-small cell lung cancer and regulates redox homeostasis.丝氨酸蛋白酶抑制剂Kazal型1是非小细胞肺癌的预后预测因子，并调节氧化还原稳态。
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Targeting SPINK1 in the damaged tumour microenvironment alleviates therapeutic resistance.针对受损肿瘤微环境中的 SPINK1 可减轻治疗抵抗。
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Global gene expression profiling reveals SPINK1 as a potential hepatocellular carcinoma marker.全球基因表达谱分析显示丝氨酸蛋白酶抑制剂 Kazal 型 1（SPINK1）是一种潜在的肝癌标志物。
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Spink13, an epididymis-specific gene of the Kazal-type serine protease inhibitor (SPINK) family, is essential for the acrosomal integrity and male fertility.Spink13 是 Kazal 型丝氨酸蛋白酶抑制剂 (SPINK) 家族的一个附睾特异性基因，对顶体完整性和男性生育能力至关重要。
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本文引用的文献
1
Therapeutic targeting of SPINK1-positive prostate cancer.靶向 SPINK1 阳性前列腺癌的治疗。
Sci Transl Med. 2011 Mar 2;3(72):72ra17. doi: 10.1126/scitranslmed.3001498.
2
Increased serum levels of tumour-associated trypsin inhibitor independently predict a poor prognosis in colorectal cancer patients.血清肿瘤相关胰蛋白酶抑制剂水平升高可独立预测结直肠癌患者预后不良。
BMC Cancer. 2010 Sep 17;10:498. doi: 10.1186/1471-2407-10-498.
3
Association of SPINK1 expression and TMPRSS2:ERG fusion with prognosis in endocrine-treated prostate cancer.SPINK1 表达和 TMPRSS2:ERG 融合与内分泌治疗前列腺癌预后的关系。
Clin Cancer Res. 2010 May 15;16(10):2845-51. doi: 10.1158/1078-0432.CCR-09-2505. Epub 2010 May 4.
4
Immunity, inflammation, and cancer.免疫、炎症与癌症。
Cell. 2010 Mar 19;140(6):883-99. doi: 10.1016/j.cell.2010.01.025.
5
Anti-epidermal growth factor receptor monoclonal antibody cetuximab plus Doxorubicin in the treatment of metastatic castration-resistant prostate cancer.抗表皮生长因子受体单克隆抗体西妥昔单抗联合多柔比星治疗转移性去势抵抗性前列腺癌。
Clin Genitourin Cancer. 2009 Oct;7(3):E77-82. doi: 10.3816/CGC.2009.n.028.
6
Erlotinib has moderate single-agent activity in chemotherapy-naïve castration-resistant prostate cancer: final results of a phase II trial.
Urology. 2009 Sep;74(3):665-71. doi: 10.1016/j.urology.2009.05.016. Epub 2009 Jul 17.
7
High expression of tumour-associated trypsin inhibitor correlates with liver metastasis and poor prognosis in colorectal cancer.肿瘤相关胰蛋白酶抑制剂的高表达与结直肠癌肝转移及不良预后相关。
Br J Cancer. 2009 May 19;100(10):1540-8. doi: 10.1038/sj.bjc.6605047. Epub 2009 Apr 21.
8
Isolation of a crystalline trypsin inhibitor-anticoagulant protein from pancreas.从胰腺中分离出一种结晶状的胰蛋白酶抑制剂-抗凝血蛋白。
J Am Chem Soc. 1948 Sep;70(9):3034-40. doi: 10.1021/ja01189a060.
9
The role of SPINK1 in ETS rearrangement-negative prostate cancers.SPINK1在ETS重排阴性前列腺癌中的作用。
Cancer Cell. 2008 Jun;13(6):519-28. doi: 10.1016/j.ccr.2008.04.016.
10
Autocrine induction of invasion and metastasis by tumor-associated trypsin inhibitor in human colon cancer cells.肿瘤相关胰蛋白酶抑制剂对人结肠癌细胞侵袭和转移的自分泌诱导作用。
Oncogene. 2008 Jul 3;27(29):4024-33. doi: 10.1038/onc.2008.42. Epub 2008 Mar 3.
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