Andreeva T N
Latvian Research Institute of Cardiology, Riga, USSR.
Cor Vasa. 1990;32(1):45-55.
Using the radioligand binding method, the authors detected differences between the calcium antagonists Foridone (FOR), nifedipine (NIF), verapamil (VER) and diltiazem (DLT) in their interaction with cardiomyocyte membrane receptors. Further, in an acute pharmacodynamic trial performed in 88 patients with essential hypertension (EH) differences between the above calcium antagonists (CA) in their influence on the mechanisms of haemodynamic regulation were discovered. The study demonstrated that the choice of CA for prolonged monotherapy of EH on the basis of pharmacodynamic trial safeguards a better therapeutic effect compared with CA administration in a randomly selected patient group. FOR proved a promising antihypertensive agent highly effective without dependence on the initial haemodynamic type of the patient; NIF is indicated in EH patients with hypokinetic circulation, VER is more effective in patients with hyperkinetic circulation. DLT has a distinct but, compared with other CA, less pronounced antihypertensive effect.
作者采用放射性配体结合法，检测了钙拮抗剂福利多（FOR）、硝苯地平（NIF）、维拉帕米（VER）和地尔硫䓬（DLT）与心肌细胞膜受体相互作用的差异。此外，在88例原发性高血压（EH）患者中进行的急性药效学试验发现，上述钙拮抗剂（CA）对血流动力学调节机制的影响存在差异。该研究表明，在药效学试验基础上选择CA进行EH的长期单一治疗，与在随机选择的患者组中使用CA相比，能保障更好的治疗效果。FOR被证明是一种有前景的抗高血压药物，高效且不依赖患者的初始血流动力学类型；NIF适用于循环动力不足的EH患者，VER对循环动力亢进的患者更有效。DLT有明显的降压作用，但与其他CA相比，其降压作用较弱。
