Surgical Neurology Branch, NINDS, National Institutes of Health, Bethesda, MD, USA.
Acta Neurochir (Wien). 2011 Aug;153(8):1551-9. doi: 10.1007/s00701-011-1050-1. Epub 2011 May 21.
In this review, we discuss the options for the surgical management of glioneuronal tumors (GNTs) associated with drug-resistant epilepsy, with an emphasis on the surgical issues involved in addressing the epileptogenic nature of these lesions. We briefly summarize the pathological hallmarks of these lesions in order to outline how these tumors contribute to seizure activity. Understanding the pathophysiology of these lesions is important in discussing the advantages and disadvantages of different surgical strategies. There have been a number of studies that have investigated the utility of different surgical approaches in improving seizure outcome, and we highlight some of these studies in order to shed light on surgical issues related to these tumors.
在这篇综述中，我们讨论了与耐药性癫痫相关的胶质神经元肿瘤 (GNT) 的手术治疗选择，重点讨论了这些病变致痫性的手术相关问题。我们简要总结了这些病变的病理特征，以阐明这些肿瘤如何引起发作活动。了解这些病变的病理生理学对于讨论不同手术策略的优缺点非常重要。已经有许多研究探讨了不同手术方法在改善癫痫发作结果方面的作用，我们强调了其中的一些研究，以便阐明与这些肿瘤相关的手术问题。
