Golic K G
Department of Genetics, University of Washington, Seattle 98195.
Genetics. 1990 May;125(1):51-76. doi: 10.1093/genetics/125.1.51.
Segregation distortion in Drosophila melanogaster is the result of an interaction between the genetic elements Sd, a Rsp sensitive to Sd, and an array of modifiers, that results in the death of sperm carrying Rsp. A stock (designated M-5; cn bw) has been constructed which has the property of inducing the partial loss of sensitivity from previously sensitive cn bw chromosomes, the partial loss of distorting ability from SD chromosomes, and a concomitant acquisition of modifiers on the X chromosome and possibly also on the autosomes. By several criteria the changes exhibited under the influence of M-5; cn bw are characteristic of the transposable-element systems which produce hybrid dysgenesis. In the first place, the magnitude of these effects depends on the nature of the crosses performed. The analogy is further strengthened by the observation that the changes induced by M-5; cn bw share other stigmata of Drosophila transposable-element systems, including high sterility among the progeny of outcrosses, and the production of chromosomal rearrangements. The possible relationship of this system to the P, I and hobo transposable element systems is discussed, as well as its bearing on aspects of the Segregation Distorter phenomenon which have yet to be explained.
黑腹果蝇中的分离畸变是遗传元件Sd、对Sd敏感的Rsp以及一系列修饰因子之间相互作用的结果，这种相互作用导致携带Rsp的精子死亡。构建了一个品系（命名为M-5；cn bw），它具有使先前敏感的cn bw染色体部分丧失敏感性、使SD染色体部分丧失畸变能力，并在X染色体上以及可能也在常染色体上伴随获得修饰因子的特性。根据几个标准，在M-5；cn bw影响下表现出的变化具有产生杂种不育的转座元件系统的特征。首先，这些效应的大小取决于所进行杂交的性质。通过观察发现M-5；cn bw诱导的变化具有果蝇转座元件系统的其他特征，包括杂交后代中的高不育性以及染色体重排的产生，这进一步加强了这种类比。讨论了该系统与P、I和hobo转座元件系统的可能关系，以及它对分离畸变现象中尚未解释的方面的影响。
